A reexamination of the concurrent discrimination learning task: the importance of anterior inferotemporal cortex, area TE. Behav Neurosci 112: 3–14

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A reexamination of the concurrent discrimination learning task: the importance of anterior inferotemporal cortex, area TE. Behav Neurosci 112: 3–14 (1998)

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by Elizabeth A. Buffalo , Lisa Stefanacci , Larry R. Squire , Stuart M. Zola

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@MISC{Buffalo98areexamination,
    author = {Elizabeth A. Buffalo and Lisa Stefanacci and Larry R. Squire and Stuart M. Zola},
    title = {A reexamination of the concurrent discrimination learning task: the importance of anterior inferotemporal cortex, area TE. Behav Neurosci 112: 3–14},
    year = {1998}
}

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Abstract

For 30 years, the concurrent discrimination learning task has figured prominently in studies used to determine the effects of medial temporal lobe damage in monkeys. However, the findings from these studies have been contradictory. We explored the contribution to concurrent discrimination performance of inadvertent damage to area TE by reexamining the behavioral data and histological material from monkeys with medial temporal lobe lesions previously tested in our laboratory. The amount of inadvertent damage to area TE was more predictive of impaired performance on the concurrent discrimination learning task than was the amount of damage to any medial temporal lobe structure, including the perirhinal cortex. These findings resolve earlier inconsistent findings regarding the concurrent discrimination learning task by demonstrating that performance on this task depends on area TE and not on perirhinal cortex or other medial temporal lobe structures. When the devastating effects on human memory of large medial temporal lobe lesions were first described (Scoville & Milner, 1957), work was immediately begun to try to establish an animal model of impaired memory in the

Keyphrases

area te concurrent discrimination anterior inferotemporal cortex behav neurosci perirhinal cortex medial temporal lobe structure inadvertent damage animal model large medial temporal lobe lesion histological material discrimination performance human memory inconsistent finding medial temporal lobe damage behavioral data impaired memory medial temporal lobe lesion scoville milner impaired performance

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