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Evolving protein interaction networks through gene duplication
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| Venue: | J. Theor. Biol |
| Citations: | 86 - 2 self |
BibTeX
@ARTICLE{Pastor-satorras_evolvingprotein,
author = {Romualdo Pastor-satorras and Eric Smith and Ricard V. Solé},
title = {Evolving protein interaction networks through gene duplication},
journal = {J. Theor. Biol},
year = {},
pages = {199--210}
}
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Abstract
The topology of the proteome map revealed by recent large-scale hybridization methods has shown that the distribution of protein-protein interactions is highly heterogeneous, with many proteins having few links while a few of them are heavily connected. This particular topology is shared by other cellular networks, such as metabolic pathways, and it has been suggested to be responsible for the high mutational homeostasis displayed by the genome of some organisms. In this paper we explore a recent model of proteome evolution that has been shown to reproduce many of the features displayed by its real counterparts. The model is based on gene duplication plus re-wiring of the newly created genes. The statistical features displayed by the proteome of well-known organisms are reproduced, suggesting that the overall topology of the protein maps naturally emerges from the two leading mechanisms considered by the model. I.
Keyphrases
gene duplication protein interaction network well-known organism proteome evolution recent large-scale hybridization method many protein metabolic pathway real counterpart protein-protein interaction cellular network overall topology proteome map high mutational homeostasis statistical feature recent model particular topology
