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A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study
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BibTeX
@MISC{Auddy_astandardized,
author = {Biswajit Auddy and Phd Jayaram Hazra and Phd Achintya Mitra and Biswajit Auddy Phd},
title = {A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study},
year = {}
}
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Abstract
Withania somnifera (WS) has historically been used in Asia for treating stress-related health conditions. In this study, we investigated the effects of standardized WS root and leaf extract (WSE) in chronically stressed humans in a modern clinical trial. Participants were randomly assigned to WSE (125 mg QD, 125 mg BID, or 250 mg BID) or placebo groups. Stress levels were assessed at Days 0, 30, and 60 using a modified Hamilton anxiety (mHAM-A) scale. Biochemical and clinical variables were measured at Days 0 and 60. Of 130 subjects enrolled, 98 completed the study. Between Days 0 and 60, the WSE 125 mg QD group decreased significantly more than placebo for mean mHAM-A score, serum cortisol, serum C-reactive protein, pulse rate and blood pressure, and increased significantly for mean serum DHEAS and hemoglobin. Other WSE treatment groups had greater dose-dependent responses in these parameters and had significantly greater responses compared to placebo in mean fasting blood glucose, serum lipid * Correspondence:
Keyphrases
placebo-controlled study standardized withania somnifera extract significantly stress-related parameter mg bid placebo group pulse rate stress level clinical variable dose-dependent response blood pressure stress-related health condition withania somnifera serum cortisol serum lipid correspondence serum c-reactive protein mean serum dheas mg qd group wse treatment group standardized w root leaf extract stressed human modern clinical trial mean fasting blood glucose hamilton anxiety mg qd mean mham-a score
