DMCA
Modelling of protein interaction networks (2001)
| Citations: | 72 - 0 self |
BibTeX
@MISC{Vazquez01modellingof,
author = {Alexei Vazquez and Ro Flammini and Amos Maritan and Ro Vespignani},
title = {Modelling of protein interaction networks},
year = {2001}
}
Share
 |
 |
 |
 |
||
OpenURL
Abstract
We introduce a graph generating model aimed at representing the evolution of protein interaction networks. The model is based on the hypotesis of evolution by duplications and divergence of the genes which produce proteins. The obtained graphs shows multifractal properties recovering the absence of a characteristic connectivity as found in real data of protein interaction networks. The error tolerance of the model to random or targeted damage is in very good agreement with the behavior obtained in real protein networks analysis. The proposed model is a first step in the identification of the evolutionary dynamics leading to the development of protein functions and interactions. PACS numbers: 89.75.-k, 87.15.Kg, 87.23.Kg Typeset using REVTEX 1 The complete genome sequencing gives for the first time the means to analyze organisms on a genomic scale. This implies the understanding of the role of a huge number of gene products and their interactions. For instance, it becomes a fundamental task to assign
Keyphrases
protein interaction network evolutionary dynamic real protein network analysis protein function huge number characteristic connectivity good agreement kg typeset real data error tolerance pac number first step complete genome fundamental task obtained graph show multifractal property first time genomic scale gene product
