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Modeling Brain Resonance Phenomena Using a Neural Mass Model
BibTeX
@MISC{Spiegler_modelingbrain,
author = {Andreas Spiegler and Thomas R. Knösche and Karin Schwab and Jens Haueisen and Fatihcan M. Atay},
title = {Modeling Brain Resonance Phenomena Using a Neural Mass Model},
year = {}
}
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Abstract
Stimulation with rhythmic light flicker (photic driving) plays an important role in the diagnosis of schizophrenia, mood disorder, migraine, and epilepsy. In particular, the adjustment of spontaneous brain rhythms to the stimulus frequency (entrainment) is used to assess the functional flexibility of the brain. We aim to gain deeper understanding of the mechanisms underlying this technique and to predict the effects of stimulus frequency and intensity. For this purpose, a modified Jansen and Rit neural mass model (NMM) of a cortical circuit is used. This mean field model has been designed to strike a balance between mathematical simplicity and biological plausibility. We reproduced the entrainment phenomenon observed in EEG during a photic driving experiment. More generally, we demonstrate that such a single area model can already yield very complex dynamics, including chaos, for biologically plausible parameter ranges. We chart the entire parameter space by means of characteristic Lyapunov spectra and Kaplan-Yorke dimension as well as time series and power spectra. Rhythmic and chaotic brain states were found virtually next to each other, such that small parameter changes can give rise to switching from one to another. Strikingly, this characteristic pattern of unpredictability generated by the model was matched to the experimental data with reasonable accuracy. These findings confirm that the NMM is a useful model of brain dynamics during photic driving. In this context, it can be used to study the mechanisms of, for example, perception and epileptic seizure generation. In particular, it enabled us to make predictions regarding the stimulus amplitude in further
Keyphrases
brain resonance phenomenon neural mass model stimulus frequency photic driving important role chaotic brain state time series characteristic lyapunov spectrum entire parameter space mean field model photic driving experiment rhythmic light flicker spontaneous brain rhythm biological plausibility kaplan-yorke dimension mood disorder cortical circuit rit neural mass model brain dynamic reasonable accuracy entrainment phenomenon small parameter change mathematical simplicity power spectrum characteristic pattern functional flexibility single area model complex dynamic stimulus amplitude epileptic seizure generation plausible parameter range experimental data useful model
