DMCA
The Growth and Cell Population Kinetics of Spontaneous Tumours in Domestic Animals (1969)
| Venue: | Br. J. Cancer |
| Citations: | 2 - 1 self |
BibTeX
@ARTICLE{Owen69thegrowth,
author = {L. N. Owen and G. G. Steel},
title = {The Growth and Cell Population Kinetics of Spontaneous Tumours in Domestic Animals},
journal = {Br. J. Cancer},
year = {1969},
pages = {493}
}
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Abstract
INVESTIGATIONS into the relationship between cell proliferation and overall tumour growth rate in human cancer have to contend with the major limitation that only rarely can both cell kinetic data and information on volume growth rate be obtained in one and the same patient. When a case is operable it is usually inadvisable to delay treatment in order to estimate growth rate; when, for instance in the case of lung secondaries, it is right to leave tumours untreated, tissue specimens are seldom available. It was to overcome this limitation that the present investigations were begun. In many cases of malignant disease in domestic animals the natural history and histopathological features are very similar to human cancer and in a proportion of these cases it is permissible to observe the course of the disease and perform simple investigations before treatment or euthanasia. The present communication covers the first nine cases which have been studied in this project. The available data on the overall growth rate of untreated tumours in man have been reviewed by Steel and Lamerton (1966). The cases from which these
Keyphrases
domestic animal cell population kinetics spontaneous tumour human cancer simple investigation present investigation untreated tumour major limitation many case lung secondary histopathological feature growth rate overall tumour growth rate volume growth rate present communication overall growth rate kinetic data malignant disease available data tissue specimen cell proliferation natural history
