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The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex..L Cell Biol (1988)
| Citations: | 143 - 8 self |
BibTeX
@MISC{Gumbiner88therole,
author = {Barry Gumbiner and Bruce Stevenson and Ann Grimaldi},
title = {The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex..L Cell Biol},
year = {1988}
}
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Abstract
Abstract. The role of the epithelial adhesion molecule uvomorulin in the formation of the epithelial junctional complex in the Madin-Darby canine kidney (MDCK) cell line was investigated. Experiments were carried out to determine whether specific inhibition of uvomorulin function would interfere selectively with the formation, stability, or function of the apical zonula adherens (ZA) and zonula occludens (ZO), or whether it would interfere with all forms of intercellular contact including the desmosomes. The effects of blocking antibodies and Fab fragments to uvomorulin on the formation of the junctional complex was examined with a Ca 2+ switch assay for de novo junction assembly. The formation of the ZO, the ZA, and the desmosomes was assayed by fluorescence staining with
Keyphrases
epithelial junctional complex cell biol cell adhesion molecule uvomorulin apical zonula adherens cell line intercellular contact junctional complex specific inhibition uvomorulin function madin-darby canine kidney switch assay fluorescence staining epithelial adhesion molecule uvomorulin fab fragment
