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Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor (1993)
| Venue: | J. Cell |
| Citations: | 37 - 5 self |
BibTeX
@ARTICLE{Deckwerth93temporalanalysis,
author = {Thomas L. Deckwerth and Eugene M. Johnson},
title = {Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor},
journal = {J. Cell},
year = {1993},
pages = {123--1207}
}
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Abstract
Abstract. The time course of molecular events that accompany degeneration and death after nerve growth factor (NGF) deprivation and neuroprotection by NGF and other agents was examined in cultures of NGFdependent neonatal rat sympathetic neurons and compared to death by apoptosis. Within 12 h after onset of NGF deprivation, glucose uptake, protein synthesis, and RNA synthesis fell precipitously followed by a moderate decrease of mitochondrial function. The molecular mechanisms underlying the NGF deprivation-induced decrease of protein synthesis and neuronal death were compared and found to be different, demonstrating that this decrease of protein synthesis is insufficient to cause death subsequently. After these early changes and during the onset of neuronal atrophy,
Keyphrases
nerve growth factor programmed cell death protein synthesis sympathetic neuron temporal analysis ngfdependent neonatal rat sympathetic neuron neuronal death ngf deprivation mitochondrial function early change glucose uptake neuronal atrophy molecular event moderate decrease ngf deprivation-induced decrease time course molecular mechanism rna synthesis
