Mapping Cognition to the Brain Through Neural Interactions (1999)
| Venue: | Memory |
| Citations: | 16 - 1 self |
BibTeX
@ARTICLE{Mcintosh99mappingcognition,
author = {Anthony Randal Mcintosh},
title = {Mapping Cognition to the Brain Through Neural Interactions},
journal = {Memory},
year = {1999},
volume = {7},
pages = {523--548}
}
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Abstract
Brain imaging methods, such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), provide a unique opportunity to study the neurobiology of human memory. Since these methods can measure most of the brain, it is possible to examine the operations of large-scale neural systems and their relation to cognition. Two neuroimaging studies, one concerning working memory and the other episodic memory retrieval, serve as examples of application of two analytic methods that are optimized for the quantification of neural systems, structural equation modeling and partial least squares. Structural equation modeling was used to explore shifting prefrontal and limbic interactions from the right to the left hemisphere in a delayed match-to-sample task for faces. A feature of the functional network for short delays was strong right hemisphere interactions between hippocampus, inferior prefrontal, and anterior cingulate cortices. At longer delays, these same three areas were strongly linked, but in the left hemisphere, which was interpreted as reflecting change in task strategy from perceptual to elaborate encoding with increasing delay. The primary manipulation in the memory retrieval study was different levels of retrieval success. Partial least squares was used to determine whether the image-wide pattern of covariances of Brodmann areas 10 and 45/47 in right prefrontal cortex (RPFC) and the left hippocampus (LGH) could be mapped on to retrieval levels. Area 10 and LGH showed an opposite pattern of functional connectivity with a large expanse of bilateral limbic cortices that was equivalent for all levels of retrieval as well as the baseline task. However, only during high retrieval area 45/47 was included in this pattern. The results suggest that activ...
