DMCA
Formulation and Evalution of pH–Induced Povidone Iodine in Situ Gel for Oralthrush
BibTeX
@MISC{K_formulationand,
author = {Jaya Raj Kumar. K and Ran. E and Srinivas. Gm},
title = {Formulation and Evalution of pH–Induced Povidone Iodine in Situ Gel for Oralthrush},
year = {}
}
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Abstract
Abstart: Candida species have become a major opportunistic pathogen causing recurrent oral thrush and oropharyngeal candidiasis topical delivery of antimicrobial agents is the most widely accepted approach aimed at prolonging active drug concentrations in the oral cavity. As most antifungal do not posses inherent ability to bind to the oral mucosa, This is best achieved through improved formulations, buccal adhesive gels are successfully used as drug delivery system consider their ability to prolong the drug release, the viscosity of the formulation was found to be in the fluid state at pH (5.8 to 6.0) before administration underwent rapid gelation upon pH 7.4. buccal in situ gels were formulated using different concentration of ion sensitive gellan gum (0.1 to 0.3),sodium alginate (0.1 to 0.5) and pH sensitive carbopol 934 (0.1 to 0.2) along with prolong release of PVP iodine (2%).formulation were evaluated for gelling capacity, viscosity, Gel strength, Bioadhesive force, spreadability drug content, FTIR and DSC.
Keyphrases
situ gel ph induced povidone iodine pvp iodine bioadhesive force prolong release antimicrobial agent major opportunistic pathogen gel strength administration underwent rapid gelation sodium alginate ion sensitive gellan gum oral cavity drug release buccal adhesive gel inherent ability recurrent oral thrush active drug concentration spreadability drug content candida specie accepted approach drug delivery system sensitive carbopol fluid state oropharyngeal candidiasis topical delivery different concentration oral mucosa improved formulation
