Abstract

strategies for repeated measures clinical trials. (Under the direction of DENNIS B. GILLINGS) In the pharmaceutical clinical trial setting, the repeated measures design is often utilized to evaluate treatment effectiveness when response to treatment manifests itself over time. For each study subject, a response vector y ' = (YI""'yp) is observed; associated with y is the vector t ' = (tl,.•.,t p) which identifies the times of observation. The use of area-under-the-time-response curve (AUC) as a measure of cumulative (or equivalently, mean) response is examined. The ANOVA model using the AUC parameter is specified. Methods to estimate AUC,

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