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Evolutionary Patterns of Non-Coding RNAs (2005)
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BibTeX
@MISC{Bompfünewerer05evolutionarypatterns,
author = {Athanasius F. Bompfünewerer and Christoph Flamm and Claudia Fried and Guido Fritzsch and Ivo L. Hofacker and Jörg Lehmann and Kristin Missal and Axel Mosig and Bettina Müller and Sonja J. Prohaska and Bärbel M. R. Stadler and Peter F. Stadler and Andrea Tanzer and Stefan Washietl and Christina Witwer},
title = {Evolutionary Patterns of Non-Coding RNAs},
year = {2005}
}
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Abstract
A plethora of new functions of non-coding RNAs have been discovered in past few years. In fact, RNA is emerging as the central player in cellular regulation, taking on active roles in multiple regulatory layers from transcription, RNA maturation, and RNA modification to translational regulation. Nevertheless, very little is known about the evolution of this “Modern RNA World ” and its components. In this contribution we attempt to provide at least a cursory overview of the diversity of non-coding RNAs and functional RNA motifs in non-translated regions of regular messenger RNAs (mRNAs) with an emphasis on evolutionary questions. This survey is complemented by an in-depth analysis of examples from different classes of RNAs focusing mostly on their evolution in the vertebrate lineage. We present a survey of Y RNA genes in vertebrates, studies of the molecular evolution of the U7 snRNA, the snoRNAs E1/U17, E2, and E3, the Y RNA family, the let-7 microRNA family, and the mRNA-like evf-1 gene. We furthermore discuss the statistical distribution
Keyphrases
non-coding rna evolutionary pattern rna family vertebrate lineage regular messenger rna mrna-like evf-1 gene evolutionary question cellular regulation non-translated region functional rna motif rna modification past year central player new function active role modern rna world u7 snrna statistical distribution rna maturation let-7 microrna family multiple regulatory layer molecular evolution in-depth analysis rna gene different class snornas e1 u17 cursory overview translational regulation
