Abstract—On chip signal compression is one of the key technologies driving development of energy efficient biotelemetry devices. In this paper, we describe a novel architecture for analog-to-digital (A/D) conversion that combines sigma delta conversion with the spatial data compression in a single module. The architecture called multiple-input multiple-output (MIMO) sigma-delta is based on a min-max gradient descent optimization of a regularized cost function that naturally leads to an A/D formulation. Experimental results with simulated and recorded multichannel data demonstrate the effectiveness of the proposed architecture to eliminate cross-channel redundancy in high density microelectrode data, thus superceding the performance of parallel independent data converters in terms of its energy efficiency. N An adaptive multiple-input multiple-output analog-to-digital converter for high density neuroprosthetic electrode arrays