Prediction-based fingerprints of protein-protein interactions (2007)
| Venue: | Proteins |
| Citations: | 9 - 0 self |
BibTeX
@ARTICLE{Porollo07prediction-basedfingerprints,
author = {Aleksey Porollo and Jarosław Meller},
title = {Prediction-based fingerprints of protein-protein interactions},
journal = {Proteins},
year = {2007},
volume = {66},
pages = {630--645}
}
OpenURL
Abstract
ABSTRACT The recognition of protein interaction sites is an important intermediate step toward identification of functionally relevant residues and understanding protein function, facilitating experimental efforts in that regard. Toward that goal, the authors propose a novel representation for the recognition of protein–protein interaction sites that integrates enhanced relative solvent accessibility (RSA) predictions with high resolution structural data. An observation that RSA predictions are biased toward the level of surface exposure consistent with protein complexes led the authors to investigate the difference between the predicted and actual (i.e., observed in an unbound structure) RSA of an amino acid residue as a fingerprint of interaction







