Predicting Protein Structure using only Sequence Information (1999)
| Venue: | Proteins |
| Citations: | 43 - 13 self |
BibTeX
@INPROCEEDINGS{Karplus99predictingprotein,
author = {Kevin Karplus and Christian Barrett and Melissa Cline and Mark Diekhans and Leslie Grate and Richard Hughey},
title = {Predicting Protein Structure using only Sequence Information},
booktitle = {Proteins},
year = {1999},
pages = {121--125}
}
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Abstract
A prediction server using the SAM-T98 method dis-This paper presents results of blind predictions subcussed here is available on the World-Wide Web mitted to the CASP3 protein structure prediction experiment. We made predictions using the SAM-T98 method, an iterative hidden Markov model based method for constructing protein family profiles. The method is purely sequence based—using no structural information—and yet was able to predict structures as well as all but five of the structure-based methods in CASP3. 1
