DMCA
Comparative Genomics of Foot-and-Mouth Disease Virus† (2004)
| Citations: | 49 - 4 self |
BibTeX
@MISC{Carrillo04comparativegenomics,
author = {C. Carrillo and E. R. Tulman and G. Delhon and Z. Lu and A. Carreno and A. Vagnozzi and G. F. Kutish and D. L. Rock},
title = {Comparative Genomics of Foot-and-Mouth Disease Virus†},
year = {2004}
}
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Abstract
Here we present complete genome sequences, including a comparative analysis, of 103 isolates of foot-andmouth disease virus (FMDV) representing all seven serotypes and including the first complete sequences of the SAT1 and SAT3 genomes. The data reveal novel highly conserved genomic regions, indicating functional constraints for variability as well as novel viral genomic motifs with likely biological relevance. Previously undescribed invariant motifs were identified in the 5 � and 3 � untranslated regions (UTR), as was tolerance for insertions/deletions in the 5 � UTR. Fifty-eight percent of the amino acids encoded by FMDV isolates are invariant, suggesting that these residues are critical for virus biology. Novel, conserved sequence motifs with likely functional significance were identified within proteins L pro, 1B, 1D, and 3C. An analysis of the complete FMDV genomes indicated phylogenetic incongruities between different genomic regions which were suggestive of interserotypic recombination. Additionally, a novel SAT virus lineage containing nonstructural proteinencoding regions distinct from other SAT and Euroasiatic lineages was identified. Insights into viral RNA sequence conservation and variability and genetic diversity in nature will likely impact our understanding of FMDV infections, host range, and transmission. Foot-and-mouth disease (FMD) is an acute, systemic disease of domestic and wild cloven-hooved animal species and is
Keyphrases
comparative genomics foot-and-mouth disease virus untranslated region euroasiatic lineage undescribed invariant motif nonstructural proteinencoding region sequence motif complete genome sequence genetic diversity novel viral genomic motif amino acid novel sat virus lineage foot-andmouth disease virus different genomic region phylogenetic incongruity genomic region data reveal interserotypic recombination functional constraint wild cloven-hooved animal specie likely biological relevance host range complete fmdv genome viral rna sequence conservation first complete sequence fifty-eight percent likely functional significance fmdv infection fmdv isolates sat3 genome insertion deletion comparative analysis systemic disease foot-and-mouth disease virus biology
