Abstract

This article considers Bayesian methods for density regression, allowing a random probability distribution to change flexibly with multiple predictors. The conditional response dis-tribution is expressed as a nonparametric mixture of parametric densities, with the mixture distri-bution changing according to location in the predictor space. A new class of priors for dependent random measures is proposed for the collection of random mixing measures at each location. The conditional prior for the random measure at a given location is expressed as a mixture of a Dirichlet process (DP) distributed innovation measure and neighboring random measures. This specifica-tion results in a coherent prior for the joint measure, with the marginal random measure at each location being a finite mixture of DP basis measures. Integrating out the infinite-dimensional col-lection of mixing measures, we obtain a simple expression for the conditional distribution of the subject-specific random variables, which generalizes the Pólya urn scheme. Properties are consid-ered and a simple Gibbs sampling algorithm is developed for posterior computation. The methods are illustrated using simulated data examples and epidemiologic studies.

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