doi:10.1016/S0092-8240(03)00030-2 Chemotactic Signaling, Microglia, and Alzheimer’s Disease Senile Plaques: Is There a Connection?
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BibTeX
@MISC{Luca_doi:10.1016/s0092-8240(03)00030-2chemotactic,
author = {Magdalena Luca and Alexandra Chavez-ross and Leah Edelstein-keshet and Alex Mogilner},
title = {doi:10.1016/S0092-8240(03)00030-2 Chemotactic Signaling, Microglia, and Alzheimer’s Disease Senile Plaques: Is There a Connection?},
year = {}
}
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Abstract
Chemotactic cells known as microglia are involved in the inflammation associated with pathology in Alzheimer’s disease (AD). We investigate conditions that lead to aggregation of microglia and formation of local accumulations of chemicals observed in AD senile plaques. We develop a model for chemotaxis in response to a combination of chemoattractant and chemorepellent signaling chemicals. Linear stability analysis and numerical simulations of the model predict that periodic patterns in cell and chemical distributions can evolve under local attraction, longranged repulsion, and other constraints on concentrations and diffusion coefficients of the chemotactic signals. Using biological parameters from the literature, we compare and discuss the applicability of this model to actual processes in AD. c ○ 2003 Society for Mathematical Biology. Published by Elsevier Science Ltd. All rights reserved. ∗Author to whom correspondence should be addressed. † Reprint address. ‡ Maternity leave.
