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Gamma Oscillations in the Entorhinal Cortex of the Freely Behaving Rat (1998)
| Venue: | Journal of Neuroscience |
| Citations: | 59 - 0 self |
BibTeX
@ARTICLE{Chrobak98gammaoscillations,
author = {J. J. Chrobak and G. Buzsáki},
title = {Gamma Oscillations in the Entorhinal Cortex of the Freely Behaving Rat},
journal = {Journal of Neuroscience},
year = {1998},
volume = {18},
pages = {388--398}
}
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Abstract
Gamma frequency field oscillations (40–100 Hz) are nested within theta oscillations in the dentate–hilar and CA1–CA3 regions of the hippocampus during exploratory behaviors. These oscillations reflect synchronized synaptic potentials that entrain the discharge of neuronal populations within the �10–25 msec range. Using multisite recordings in freely behaving rats, we examined gamma oscillations within the superficial layers (I–III) of the entorhinal cortex. These oscillations increased in amplitude and regularity in association with entorhinal theta waves. Gamma waves showed an amplitude minimum and reversed in phase near the perisomatic region of layer II, indicating that they represent synchronized synaptic potentials impinging on layer II–III neurons. Theta and gamma oscillations in the entorhinal cortex were coupled with theta and gamma oscillations in the dentate hilar region. The majority of layer II–III neurons “The ultimate physical substrate of memory formation and consolidation resides in alteration in synaptic efficacy, which then alters the patterns of activity in large aggregate collections of cortical neurons ” (Hebb, 1949). It is the modifications in the patterns of activity in large aggregate collections of neurons that have relevance to the cognitive operations of the mammalian brain. The means by which large collections of neurons, within and across vast regions of the brain, can effectively interact is not well understood. The occurrence and transient sychronization of neurons to local field oscillations has been demonstrated in many neural
Keyphrases
gamma oscillation entorhinal cortex freely behaving rat large aggregate collection synaptic potential dentate hilar region layer ii gamma frequency field oscillation exploratory behavior superficial layer neuronal population mammalian brain entorhinal theta wave dentate hilar theta oscillation multisite recording layer ii iii msec range memory formation transient sychronization synaptic efficacy cortical neuron consolidation resides ca1 ca3 region vast region large collection layer ii iii neuron perisomatic region amplitude minimum ultimate physical substrate cognitive operation local field oscillation
