DMCA
Unit on Dynamic Imaging Genetics, (2006)
BibTeX
@MISC{Buckholtz06uniton,
author = {Joshua W. Buckholtz and Andreas Meyer-lindenberg and Robyn A. Honea and Richard E. Straub and Lukas Pezawas and Michael F. Egan and Radhakrishna Vakkalanka and Bhaskar Kolachana and Beth A. Verchinski and Steven Sust and Venkata S. Mattay and Daniel R. Weinberger and Joseph H. Callicott and Neuroimaging Core Facility},
title = {Unit on Dynamic Imaging Genetics,},
year = {2006}
}
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Abstract
Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of G�-GTP binding. Linkage, association, and postmortem studies have implicated the gene encoding RGS4 (RGS4) as a schizophrenia susceptibility factor. Using a multimodal neuroimaging approach, we demonstrate that genetic variation in RGS4 is associated with functional activation and connectivity during working memory in the absence of overt behavioral differences, with regional gray and white matter volume and with gray matter structural connectivity in healthy human subjects. Specifically, variation at one RGS4 single nucleotide polymorphism that has been associated previously with psychosis (rs951436) impacts frontoparietal and frontotemporal blood oxygenation level-dependent response and network coupling during working memory and results in regionally specific reductions in gray and white matter structural volume in individuals carrying the A allele. These findings suggest mechanisms in brain for the association of RGS4 with risk for psychiatric illness.
Keyphrases
dynamic imaging genetics specific reduction frontotemporal blood oxygenation level-dependent response postmortem study psychiatric illness postsynaptic signal transduction gtp binding regional gray gray matter structural connectivity functional activation healthy human subject white matter volume white matter structural volume overt behavioral difference schizophrenia susceptibility factor genetic variation
