DMCA
A Neuroendocrine Carcinoma of Undetermined Origin in a Dog
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BibTeX
@MISC{Kuwata_aneuroendocrine,
author = {Kazunori Kuwata and Makoto Shibutani and Yusuke Kemmochi and Eriko Taniai and Reiko Morita and Bunichiro Ogawa and Kunitoshi Mitsumori},
title = {A Neuroendocrine Carcinoma of Undetermined Origin in a Dog},
year = {}
}
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Abstract
Abstract: In this report, we describe a case of neuroendocrine carcinoma of undetermined origin in a dog. Necropsy revealed scattered small neoplastic nodules in the bilateral lungs and a small nodule in the parapancreatic lymph node. Histopathologically, both pulmonary and lymph nodal nodules showed a similar histologic pattern, with neoplastic cells being arranged in diffusely proliferating sheet-like cellular nests separated by variable amounts of fibrous septa, sometimes forming rosettes and duct-like structures. Scattered small necrotic foci and invasion to fibrous septa were typically observed. Neoplastic cells showed round to oval-shaped nuclei with prominent nucleoli and abundant eosinophilic cytoplasm that were positive for Grimelius ’ silver impregnation staining and immunostaining with cytokeratin, synaptophysin, vasoactive intestinal peptide and chromogranin A, indicative of the development of a neuroendocrine carcinoma. However, judging from the distribution of tumors lacking the portion suggestive of the primary site in any organ examined, as well as no further indication of differentiation potential of neoplastic cells, this tumor has so far been diagnosed as neuroendocrine carcinoma of undetermined origin. (J Toxicol Pathol 2010; 23:
Keyphrases
neuroendocrine carcinoma undetermined origin neoplastic cell fibrous septum primary site vasoactive intestinal peptide toxicol pathol oval-shaped nucleus portion suggestive bilateral lung variable amount duct-like structure grimelius silver impregnation staining parapancreatic lymph node small nodule scattered small necrotic focus differentiation potential small neoplastic nodule similar histologic pattern prominent nucleolus abundant eosinophilic cytoplasm lymph nodal nodule sheet-like cellular nest
