DMCA
The Self-Organizing Brain: From Growth Cones to Functional Networks Editors: J. van Pelt, M.A. Corner, H.B.M. Uylings and F.H. Lopes da Silva
BibTeX
@MISC{Schutter_theself-organizing,
author = {E. De Schutter},
title = {The Self-Organizing Brain: From Growth Cones to Functional Networks Editors: J. van Pelt, M.A. Corner, H.B.M. Uylings and F.H. Lopes da Silva},
year = {}
}
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Abstract
The cerebellar Purkinje cell is among the largest and most complex neurons in the mammalian brain. The 150,000 to 175,000 granule cell inputs received by each Purkinje cell (Harvey and Napper, 1991) constitute the most massive synaptic convergence found on any neuron in the brain (Shepherd, 1990). Purkinje cells are also distinguished by high densities of Ca2+ channels on the dendrite and by a complex apparatus controlling cytoplasmic Ca2+ concentrations, e.g., with cytoplasmic Ca2+ stores possessing IP3 and ryanodine receptors (Brorson et al., 1991), metabotropic receptors (Llano et al., 1991; Staub et al., 1992) and Ca2+ inflow through the Ca2+ channels (Hockberger et al., 1989; Lev-Ram et al., 1992). Numerous physiological (Llinás and Sugimori, 1992) and biochemical studies (Ito, 1984) have provided the neuroscience community with a wealth of details on the firing properties of Purkinje cells in vitro and on the identity and kinetics of synaptic and ionic channels, but an integrated view of how all these
Keyphrases
purkinje cell h.b.m. uylings f.h. lope da silva self-organizing brain van pelt m.a. corner growth cone functional network editor ca2 channel complex apparatus cytoplasmic ca2 concentration complex neuron firing property neuroscience community mammalian brain integrated view granule cell input ryanodine receptor ionic channel metabotropic receptor biochemical study massive synaptic convergence cerebellar purkinje cell high density cytoplasmic ca2 store
