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Three-dimensional relationships between hippocampal synapses and astrocytes (1999)
| Venue: | J Neurosci |
| Citations: | 95 - 1 self |
BibTeX
@ARTICLE{Ventura99three-dimensionalrelationships,
author = {Rachel Ventura and Kristen M. Harris},
title = {Three-dimensional relationships between hippocampal synapses and astrocytes},
journal = {J Neurosci},
year = {1999}
}
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Abstract
Recent studies show that glutamate transporter-mediated currents occur in astrocytes when glutamate is released from hippocampal synapses. These transporters remove excess glutamate from the extracellular space, thereby facilitating synaptic input specificity and preventing neurotoxicity. Little is known about the position of astrocytic processes at hippocampal synapses. Serial electron microscopy and three-dimensional analyses were used to investigate structural relationships between astrocytes and synapses in stratum radiatum of hippocampal area CA1 in the mature rat in vivo and in slices. Only 57 � 11 % of the synapses had astrocytic processes apposed to them. Of these, the astrocytic processes surrounded less than half (0.43 � 22) of the synaptic interface. Other studies suggest that astrocytes extend processes toward higher concentrations of glutamate; thus the presence of astrocytic processes
Keyphrases
hippocampal synapsis astrocytic process three-dimensional relationship hippocampal area ca1 synaptic input specificity stratum radiatum three-dimensional analysis recent study mature rat serial electron microscopy glutamate transporter-mediated current synaptic interface structural relationship excess glutamate extracellular space
