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Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125: 301–313 (2006)
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@MISC{Lee06controlof,
author = {Tong Ihn Lee and Richard G. Jenner and Laurie A. Boyer and Matthew G. Guenther and Stuart S. Levine and Arie P. Otte and Thomas L. Volkert and David P. Bartel and Douglas A. Melton and David K. Gifford and Rudolf Jaenisch and Richard A. Young},
title = {Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125: 301–313},
year = {2006}
}
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Abstract
Polycomb group proteins are essential for early development in metazoans, but their contributions to human development are not well understood. We have mapped the Polycomb Repressive Complex 2 (PRC2) subunit SUZ12 across the entire nonrepeat portion of the genome in human embryonic stem (ES) cells. We found that SUZ12 is distributed across large portions of over two hundred genes encoding key developmental regulators. These genes are occupied by nucleosomes trimethylated at histone H3K27, are transcriptionally repressed, and contain some of the most highly conserved noncoding elements in the genome. We found that PRC2 target genes are preferentially activated during ES cell differentiation
Keyphrases
developmental regulator human embryonic stem cell human development entire nonrepeat portion prc2 target gene polycomb repressive complex e cell differentiation polycomb group protein human embryonic stem early development subunit suz12 key developmental regulator large portion histone h3k27 hundred gene
