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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory and preparative actions. Endocrine Rev 21:55–89 (2000)
| Citations: | 330 - 8 self |
BibTeX
@MISC{Sapolsky00howdo,
author = {Robert M. Sapolsky and L. Michael Romero and Allan and U. Munck},
title = {How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory and preparative actions. Endocrine Rev 21:55–89},
year = {2000}
}
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Abstract
The secretion of glucocorticoids (GCs) is a classic endocrine re-sponse to stress. Despite that, it remains controversial as to what purpose GCs serve at such times. One view, stretching back to the time of Hans Selye, posits that GCs help mediate the ongoing or pending stress response, either via basal levels of GCs permitting other facets of the stress response to emerge efficaciously, and/or by stress levels of GCs actively stimulating the stress response. In con-trast, a revisionist viewpoint posits that GCs suppress the stress response, preventing it from being pathologically overactivated. In this review, we consider recent findings regarding GC action and, based on them, generate criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor. We apply these GC actions to the realms of cardiovascular function, fluid volume and hemorrhage, immunity and inflammation, metabolism, neurobiology, and reproductive physiology. We find that GC actions fall into markedly different categories, depending on the physiological endpoint in question, with evidence for mediating ef-fects in some cases, and suppressive or preparative in others. We then attempt to assimilate these heterogeneous GC actions into a physi-ological whole. (Endocrine Reviews 21: 55–89, 2000)
Keyphrases
stress response preparative action endocrine rev gc action recent finding heterogeneous gc action fluid volume revisionist viewpoint posit classic endocrine re-sponse basal level han selye gc help physi-ological whole stress level different category subsequent stressor physiological endpoint ongoing stress-response additional category particular gc action permit reproductive physiology cardiovascular function
