DMCA
and adjacent regions in Caenorhnbditis elegnns
BibTeX
@MISC{Charest_andadjacent,
author = {David L. Charest and Denise V. Clark and Michael E. Green and David L. Baillie},
title = {and adjacent regions in Caenorhnbditis elegnns},
year = {}
}
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Abstract
Summary. The genetic organization of une-26(IV) and adjacent regions was studied in Caenorhabditis elegans. We constructed a fine structure genetic map of unc-26(IV), a gene that affects locomotion and pharyngeal muscle movement but not muscle structure. Eleven alleles were positioned relative to each other recombinationally and were classified according to phenotypic severity. The unc-26 gene spans at least 0.026 map units, which is exceptionally large for a C. elegans gene. All but one allele, e205, are amorphic alleles. Interestingly, e205 is hypomorphic but also suppressible by the amber suppressor sup-7. Nineteen lethal mutations in the unc-26 region were isolated and characterized. The unc-26 region is subdivided into four zones by five deficiency breakpoints. These mutations fall into 15 complementation groups. The stages of development affected by these mutations were determined.
Keyphrases
adjacent region caenorhnbditis elegnns unc-26 region muscle structure nineteen lethal mutation unc-26 gene span caenorhabditis elegans pharyngeal muscle movement eleven allele fine structure genetic map elegans gene genetic organization map unit phenotypic severity amber suppressor sup-7 deficiency breakpoints amorphic allele complementation group
