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...ple regression analyses (15). When significant differences were found between more than two groups by variance analysis, each interesting pair of groups was compared by the Bonferroni adjusted t test =-=(4)-=-. The Mann-Whitney nonparametric U test was used for nonnormally distributed values. Differences in values were considered significant if theP value was <0.05 or 0.05 divided by the number of tests ma...

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...rded on days 0, 2, and 7. The in vitro chemosusceptibilities of the parasite isolates to Cq and ApQ were assessed on day 0 by a semimicrotest that measured the incorporation of tritiated hypoxanthine =-=(11)-=-. Quantitative asexual parasite counts were determined on Giemsa-stained thick blood smears on days 0, 2, and 7. ApQ concentrations in whole blood were measured on day 2 by a high-performance liquid c...

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...eterminants of an immediate therapeutic response, the time of administration of antimalarial agents with widely fluctuating concentrations (as was the case for ApQ) could influence treatment efficacy =-=(18)-=-. This improved efficacy of timed chloroquine treatment was recently demonstrated in P. falciparum-infected patients (the midterm trophozoites of P. falciparum being the VOL. 37, 1993 5 n . 5. In .0 D...

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...r of chloroquine (Cq) and then Aq, interest in ApQ is now renewed following the extensive development of resistance to Cq and the appearance of severe side effects with Aq after prolonged prophylaxis =-=(2, 6)-=-. Since no pharmacokinetic studies of ApQ were available, we initially studied its metabolism and kinetics in the rat and rabbit (13) and then in healthy human volunteers (16), using the dosage of 3 m...

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...r of chloroquine (Cq) and then Aq, interest in ApQ is now renewed following the extensive development of resistance to Cq and the appearance of severe side effects with Aq after prolonged prophylaxis =-=(2, 6)-=-. Since no pharmacokinetic studies of ApQ were available, we initially studied its metabolism and kinetics in the rat and rabbit (13) and then in healthy human volunteers (16), using the dosage of 3 m...

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... prolonged prophylaxis (2, 6). Since no pharmacokinetic studies of ApQ were available, we initially studied its metabolism and kinetics in the rat and rabbit (13) and then in healthy human volunteers =-=(16)-=-, using the dosage of 3 mg/kg, which was initially effective. At the same time, multicenter studies in patients with acute malaria showed a poor efficacy when 3 mg/kg was used (16% in Gabon [n = 79]; ...

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...arum being the VOL. 37, 1993 5 n . 5. In .0 D CD U] -0 CL. Pzso nsM arch 5, 2016 by PENN STATE UNIV http://aac.asm .org/ D ow nloaded from ANTIMICROB. AGENTS CHEMOTHER. most susceptible stages to Cq) =-=(9)-=-. The susceptibility of the parasite to ApQ might be also stage dependent. It is likely that the conjunction of all of these factors, particularly the large parasite burden, low level of immunity, and...

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... 2, and 7. ApQ concentrations in whole blood were measured on day 2 by a high-performance liquid chromatographic (HPLC) method (12). Because of frequent and often heavy self-medication with Cq and Aq =-=(17)-=-, the most available and most widely used drugs in Gabon, these drugs and their respective metabolites were simultaneously checked with ApQ by HPLC on day 2, in addition to the day 0 urine 4-aminoquin...

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...us adverse reactions to 4-aminoquinolines. On admission, the presence of other 4-aminoquinolines self-prescribed by the patients was evaluated by a urine test with a detection limit of 10 ,umol/liter =-=(1)-=-. Of the 175 patients initially recruited for the study, 6 were eliminated because no follow-up of drug levels on day 2 was possible and 17 others were eliminated because their parasite count was not ...

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...ich was demonstrated nearly 30 years ago to be effective in the treatment of Plasmodium falciparum and Plasmodium vivax malaria when given as a single 3-mg/kg (of body weight) intramuscular injection =-=(7, 8, 14)-=-. After being abandoned in favor of chloroquine (Cq) and then Aq, interest in ApQ is now renewed following the extensive development of resistance to Cq and the appearance of severe side effects with ...

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...ich was demonstrated nearly 30 years ago to be effective in the treatment of Plasmodium falciparum and Plasmodium vivax malaria when given as a single 3-mg/kg (of body weight) intramuscular injection =-=(7, 8, 14)-=-. After being abandoned in favor of chloroquine (Cq) and then Aq, interest in ApQ is now renewed following the extensive development of resistance to Cq and the appearance of severe side effects with ...

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...te counts were determined on Giemsa-stained thick blood smears on days 0, 2, and 7. ApQ concentrations in whole blood were measured on day 2 by a high-performance liquid chromatographic (HPLC) method =-=(12)-=-. Because of frequent and often heavy self-medication with Cq and Aq (17), the most available and most widely used drugs in Gabon, these drugs and their respective metabolites were simultaneously chec...

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...rance of severe side effects with Aq after prolonged prophylaxis (2, 6). Since no pharmacokinetic studies of ApQ were available, we initially studied its metabolism and kinetics in the rat and rabbit =-=(13)-=- and then in healthy human volunteers (16), using the dosage of 3 mg/kg, which was initially effective. At the same time, multicenter studies in patients with acute malaria showed a poor efficacy when...

Citation Context

...ich was demonstrated nearly 30 years ago to be effective in the treatment of Plasmodium falciparum and Plasmodium vivax malaria when given as a single 3-mg/kg (of body weight) intramuscular injection =-=(7, 8, 14)-=-. After being abandoned in favor of chloroquine (Cq) and then Aq, interest in ApQ is now renewed following the extensive development of resistance to Cq and the appearance of severe side effects with ...