Copyright © 1993, American Society for Microbiology Efficacy of Intramuscular Amopyroquin for Treatment of Plasmodium falciparum Malaria in the Gabon Republic (1992)
Citations
49 |
Comparing the means of several groups.
- Godfrey
- 1985
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Citation Context ...ple regression analyses (15). When significant differences were found between more than two groups by variance analysis, each interesting pair of groups was compared by the Bonferroni adjusted t test =-=(4)-=-. The Mann-Whitney nonparametric U test was used for nonnormally distributed values. Differences in values were considered significant if theP value was <0.05 or 0.05 divided by the number of tests ma... |
20 |
In vitro study of drug sensitivity of Plasmodium falciparum: evaluation of a new semi-microtest.
- Bras, Deloron
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Citation Context ...rded on days 0, 2, and 7. The in vitro chemosusceptibilities of the parasite isolates to Cq and ApQ were assessed on day 0 by a semimicrotest that measured the incorporation of tritiated hypoxanthine =-=(11)-=-. Quantitative asexual parasite counts were determined on Giemsa-stained thick blood smears on days 0, 2, and 7. ApQ concentrations in whole blood were measured on day 2 by a high-performance liquid c... |
15 |
Antimalarial pharmacokinetics and treatment regimens.
- White
- 1992
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Citation Context ...eterminants of an immediate therapeutic response, the time of administration of antimalarial agents with widely fluctuating concentrations (as was the case for ApQ) could influence treatment efficacy =-=(18)-=-. This improved efficacy of timed chloroquine treatment was recently demonstrated in P. falciparum-infected patients (the midterm trophozoites of P. falciparum being the VOL. 37, 1993 5 n . 5. In .0 D... |
7 |
Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. Lancet
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Citation Context ...r of chloroquine (Cq) and then Aq, interest in ApQ is now renewed following the extensive development of resistance to Cq and the appearance of severe side effects with Aq after prolonged prophylaxis =-=(2, 6)-=-. Since no pharmacokinetic studies of ApQ were available, we initially studied its metabolism and kinetics in the rat and rabbit (13) and then in healthy human volunteers (16), using the dosage of 3 m... |
4 |
Ketoconarole-induced fulminate hepatitis.
- Bernuau, Degott, et al.
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Citation Context ...r of chloroquine (Cq) and then Aq, interest in ApQ is now renewed following the extensive development of resistance to Cq and the appearance of severe side effects with Aq after prolonged prophylaxis =-=(2, 6)-=-. Since no pharmacokinetic studies of ApQ were available, we initially studied its metabolism and kinetics in the rat and rabbit (13) and then in healthy human volunteers (16), using the dosage of 3 m... |
4 |
Pharmacokinetics of intramuscular amopyroquin in healthy subjects and determination of a therapeutic regimen for Plasmodium falciparum malaria. Antimicrobial Agents and Chemotherapy
- Verdier, Pussard, et al.
- 1989
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Citation Context ... prolonged prophylaxis (2, 6). Since no pharmacokinetic studies of ApQ were available, we initially studied its metabolism and kinetics in the rat and rabbit (13) and then in healthy human volunteers =-=(16)-=-, using the dosage of 3 mg/kg, which was initially effective. At the same time, multicenter studies in patients with acute malaria showed a poor efficacy when 3 mg/kg was used (16% in Gabon [n = 79]; ... |
3 | Cerebral malaria. - Marsden, Bruce-Chwatt - 1975 |
3 |
Chronotherapy of malaria: improved effi cacy of timed chloroquine treatment of patients with Plas modium falciparum infections. Transactions of the Royal Society of Tropical Medicine and Hygiene
- LANDAU, LEPERS, et al.
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Citation Context ...arum being the VOL. 37, 1993 5 n . 5. In .0 D CD U] -0 CL. Pzso nsM arch 5, 2016 by PENN STATE UNIV http://aac.asm .org/ D ow nloaded from ANTIMICROB. AGENTS CHEMOTHER. most susceptible stages to Cq) =-=(9)-=-. The susceptibility of the parasite to ApQ might be also stage dependent. It is likely that the conjunction of all of these factors, particularly the large parasite burden, low level of immunity, and... |
3 |
Unreliability of the Dill-Glazko test in detecting chloroquine in urine. Lancet i:182
- Verdier, RamanamiriJa, et al.
- 1985
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Citation Context ... 2, and 7. ApQ concentrations in whole blood were measured on day 2 by a high-performance liquid chromatographic (HPLC) method (12). Because of frequent and often heavy self-medication with Cq and Aq =-=(17)-=-, the most available and most widely used drugs in Gabon, these drugs and their respective metabolites were simultaneously checked with ApQ by HPLC on day 2, in addition to the day 0 urine 4-aminoquin... |
2 |
Determination of chloroquine and its metabolites in urine: a field method based on ion-pair extraction
- Bergqvist, Hed, et al.
- 1985
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Citation Context ...us adverse reactions to 4-aminoquinolines. On admission, the presence of other 4-aminoquinolines self-prescribed by the patients was evaluated by a urine test with a detection limit of 10 ,umol/liter =-=(1)-=-. Of the 175 patients initially recruited for the study, 6 were eliminated because no follow-up of drug levels on day 2 was possible and 17 others were eliminated because their parasite count was not ... |
1 | Stabilite de la resistance a la chloroquine de Plasmodium falciparum entre 1987 et 1989 a - Bull |
1 |
Propoquin in treatment of malaria
- Hockenga
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Citation Context ...ich was demonstrated nearly 30 years ago to be effective in the treatment of Plasmodium falciparum and Plasmodium vivax malaria when given as a single 3-mg/kg (of body weight) intramuscular injection =-=(7, 8, 14)-=-. After being abandoned in favor of chloroquine (Cq) and then Aq, interest in ApQ is now renewed following the extensive development of resistance to Cq and the appearance of severe side effects with ... |
1 |
Intramuscular amopyroquin for acute malaria
- Hockenga
- 1962
(Show Context)
Citation Context ...ich was demonstrated nearly 30 years ago to be effective in the treatment of Plasmodium falciparum and Plasmodium vivax malaria when given as a single 3-mg/kg (of body weight) intramuscular injection =-=(7, 8, 14)-=-. After being abandoned in favor of chloroquine (Cq) and then Aq, interest in ApQ is now renewed following the extensive development of resistance to Cq and the appearance of severe side effects with ... |
1 |
Liquid chromatographic determination of amopyroquin in rabbit plasma and red blood cells
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- 1987
(Show Context)
Citation Context ...te counts were determined on Giemsa-stained thick blood smears on days 0, 2, and 7. ApQ concentrations in whole blood were measured on day 2 by a high-performance liquid chromatographic (HPLC) method =-=(12)-=-. Because of frequent and often heavy self-medication with Cq and Aq (17), the most available and most widely used drugs in Gabon, these drugs and their respective metabolites were simultaneously chec... |
1 |
Disposition of amopyroquin in rats and rabbits and in vitro activity against Plasmodium falciparum. Antimicrob. Agents Chemother
- Pussard, Verdier, et al.
- 1988
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Citation Context ...rance of severe side effects with Aq after prolonged prophylaxis (2, 6). Since no pharmacokinetic studies of ApQ were available, we initially studied its metabolism and kinetics in the rat and rabbit =-=(13)-=- and then in healthy human volunteers (16), using the dosage of 3 mg/kg, which was initially effective. At the same time, multicenter studies in patients with acute malaria showed a poor efficacy when... |
1 |
Results of clinical trials on the parenteral application of propoquin (PAM.780), a new antimalarial
- Rathscheck
- 1959
(Show Context)
Citation Context ...ich was demonstrated nearly 30 years ago to be effective in the treatment of Plasmodium falciparum and Plasmodium vivax malaria when given as a single 3-mg/kg (of body weight) intramuscular injection =-=(7, 8, 14)-=-. After being abandoned in favor of chloroquine (Cq) and then Aq, interest in ApQ is now renewed following the extensive development of resistance to Cq and the appearance of severe side effects with ... |