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744
Using Bayesian networks to analyze expression data
 Journal of Computational Biology
, 2000
"... DNA hybridization arrays simultaneously measure the expression level for thousands of genes. These measurements provide a “snapshot ” of transcription levels within the cell. A major challenge in computational biology is to uncover, from such measurements, gene/protein interactions and key biologica ..."
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Cited by 731 (16 self)
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DNA hybridization arrays simultaneously measure the expression level for thousands of genes. These measurements provide a “snapshot ” of transcription levels within the cell. A major challenge in computational biology is to uncover, from such measurements, gene/protein interactions and key biological features of cellular systems. In this paper, we propose a new framework for discovering interactions between genes based on multiple expression measurements. This framework builds on the use of Bayesian networks for representing statistical dependencies. A Bayesian network is a graphbased model of joint multivariate probability distributions that captures properties of conditional independence between variables. Such models are attractive for their ability to describe complex stochastic processes and because they provide a clear methodology for learning from (noisy) observations. We start by showing how Bayesian networks can describe interactions between genes. We then describe a method for recovering gene interactions from microarray data using tools for learning Bayesian networks. Finally, we demonstrate this method on the S. cerevisiae cellcycle measurements of Spellman et al. (1998). Key words: gene expression, microarrays, Bayesian methods. 1.
Bayesian Network Classifiers
, 1997
"... Recent work in supervised learning has shown that a surprisingly simple Bayesian classifier with strong assumptions of independence among features, called naive Bayes, is competitive with stateoftheart classifiers such as C4.5. This fact raises the question of whether a classifier with less restr ..."
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Cited by 587 (22 self)
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Recent work in supervised learning has shown that a surprisingly simple Bayesian classifier with strong assumptions of independence among features, called naive Bayes, is competitive with stateoftheart classifiers such as C4.5. This fact raises the question of whether a classifier with less restrictive assumptions can perform even better. In this paper we evaluate approaches for inducing classifiers from data, based on the theory of learning Bayesian networks. These networks are factored representations of probability distributions that generalize the naive Bayesian classifier and explicitly represent statements about independence. Among these approaches we single out a method we call Tree Augmented Naive Bayes (TAN), which outperforms naive Bayes, yet at the same time maintains the computational simplicity (no search involved) and robustness that characterize naive Bayes. We experimentally tested these approaches, using problems from the University of California at Irvine repository, and compared them to C4.5, naive Bayes, and wrapper methods for feature selection.
Markov Logic Networks
 Machine Learning
, 2006
"... Abstract. We propose a simple approach to combining firstorder logic and probabilistic graphical models in a single representation. A Markov logic network (MLN) is a firstorder knowledge base with a weight attached to each formula (or clause). Together with a set of constants representing objects ..."
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Cited by 569 (34 self)
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Abstract. We propose a simple approach to combining firstorder logic and probabilistic graphical models in a single representation. A Markov logic network (MLN) is a firstorder knowledge base with a weight attached to each formula (or clause). Together with a set of constants representing objects in the domain, it specifies a ground Markov network containing one feature for each possible grounding of a firstorder formula in the KB, with the corresponding weight. Inference in MLNs is performed by MCMC over the minimal subset of the ground network required for answering the query. Weights are efficiently learned from relational databases by iteratively optimizing a pseudolikelihood measure. Optionally, additional clauses are learned using inductive logic programming techniques. Experiments with a realworld database and knowledge base in a university domain illustrate the promise of this approach.
Dynamic Bayesian Networks: Representation, Inference and Learning
, 2002
"... Modelling sequential data is important in many areas of science and engineering. Hidden Markov models (HMMs) and Kalman filter models (KFMs) are popular for this because they are simple and flexible. For example, HMMs have been used for speech recognition and biosequence analysis, and KFMs have bee ..."
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Cited by 564 (3 self)
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Modelling sequential data is important in many areas of science and engineering. Hidden Markov models (HMMs) and Kalman filter models (KFMs) are popular for this because they are simple and flexible. For example, HMMs have been used for speech recognition and biosequence analysis, and KFMs have been used for problems ranging from tracking planes and missiles to predicting the economy. However, HMMs
and KFMs are limited in their “expressive power”. Dynamic Bayesian Networks (DBNs) generalize HMMs by allowing the state space to be represented in factored form, instead of as a single discrete random variable. DBNs generalize KFMs by allowing arbitrary probability distributions, not just (unimodal) linearGaussian. In this thesis, I will discuss how to represent many different kinds of models as DBNs, how to perform exact and approximate inference in DBNs, and how to learn DBN models from sequential data.
In particular, the main novel technical contributions of this thesis are as follows: a way of representing
Hierarchical HMMs as DBNs, which enables inference to be done in O(T) time instead of O(T 3), where T is the length of the sequence; an exact smoothing algorithm that takes O(log T) space instead of O(T); a simple way of using the junction tree algorithm for online inference in DBNs; new complexity bounds on exact online inference in DBNs; a new deterministic approximate inference algorithm called factored frontier; an analysis of the relationship between the BK algorithm and loopy belief propagation; a way of
applying RaoBlackwellised particle filtering to DBNs in general, and the SLAM (simultaneous localization
and mapping) problem in particular; a way of extending the structural EM algorithm to DBNs; and a variety of different applications of DBNs. However, perhaps the main value of the thesis is its catholic presentation of the field of sequential data modelling.
Active Learning with Statistical Models
, 1995
"... For manytypes of learners one can compute the statistically "optimal" way to select data. We review how these techniques have been used with feedforward neural networks [MacKay, 1992# Cohn, 1994]. We then showhow the same principles may be used to select data for two alternative, statisticallybas ..."
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Cited by 529 (10 self)
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For manytypes of learners one can compute the statistically "optimal" way to select data. We review how these techniques have been used with feedforward neural networks [MacKay, 1992# Cohn, 1994]. We then showhow the same principles may be used to select data for two alternative, statisticallybased learning architectures: mixtures of Gaussians and locally weighted regression. While the techniques for neural networks are expensive and approximate, the techniques for mixtures of Gaussians and locally weighted regression are both efficient and accurate.
Learning probabilistic relational models
 In IJCAI
, 1999
"... A large portion of realworld data is stored in commercial relational database systems. In contrast, most statistical learning methods work only with "flat " data representations. Thus, to apply these methods, we are forced to convert our data into a flat form, thereby losing much of the r ..."
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Cited by 510 (28 self)
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A large portion of realworld data is stored in commercial relational database systems. In contrast, most statistical learning methods work only with "flat " data representations. Thus, to apply these methods, we are forced to convert our data into a flat form, thereby losing much of the relational structure present in our database. This paper builds on the recent work on probabilistic relational models (PRMs), and describes how to learn them from databases. PRMs allow the properties of an object to depend probabilistically both on other properties of that object and on properties of related objects. Although PRMs are significantly more expressive than standard models, such as Bayesian networks, we show how to extend wellknown statistical methods for learning Bayesian networks to learn these models. We describe both parameter estimation and structure learning — the automatic induction of the dependency structure in a model. Moreover, we show how the learning procedure can exploit standard database retrieval techniques for efficient learning from large datasets. We present experimental results on both real and synthetic relational databases. 1
Inductive Learning Algorithms and Representations for Text Categorization
, 1998
"... Text categorization – the assignment of natural language texts to one or more predefined categories based on their content – is an important component in many information organization and management tasks. We compare the effectiveness of five different automatic learning algorithms for text categori ..."
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Cited by 501 (9 self)
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Text categorization – the assignment of natural language texts to one or more predefined categories based on their content – is an important component in many information organization and management tasks. We compare the effectiveness of five different automatic learning algorithms for text categorization in terms of learning speed, realtime classification speed, and classification accuracy. We also examine training set size, and alternative document representations. Very accurate text classifiers can be learned automatically from training examples. Linear Support Vector Machines (SVMs) are particularly promising because they are very accurate, quick to train, and quick to evaluate. 1.1 Keywords Text categorization, classification, support vector machines, machine learning, information management.
A bayesian approach to filtering junk Email, in: Learning for Text Categorization
 Papers from the 1998 Workshop, AAAI
, 1998
"... In addressing the growing problem of junk Email on the Internet, we examine methods for the automated construction of filters to eliminate such unwanted messages from a user’s mail stream. By casting this problem in a decision theoretic framework, we are able to make use of probabilistic learning m ..."
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Cited by 386 (6 self)
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In addressing the growing problem of junk Email on the Internet, we examine methods for the automated construction of filters to eliminate such unwanted messages from a user’s mail stream. By casting this problem in a decision theoretic framework, we are able to make use of probabilistic learning methods in conjunction with a notion of differential misclassification cost to produce filters Which are especially appropriate for the nuances of this task. While this may appear, at first, to be a straightforward text classification problem, we show that by considering domainspecific features of this problem in addition to the raw text of Email messages, we can produce much more accurate filters. Finally, we show the efficacy of such filters in a real world usage scenario, arguing that this technology is mature enough for deployment.
Estimating Continuous Distributions in Bayesian Classifiers
 In Proceedings of the Eleventh Conference on Uncertainty in Artificial Intelligence
, 1995
"... When modeling a probability distribution with a Bayesian network, we are faced with the problem of how to handle continuous variables. Most previous work has either solved the problem by discretizing, or assumed that the data are generated by a single Gaussian. In this paper we abandon the normality ..."
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Cited by 311 (2 self)
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When modeling a probability distribution with a Bayesian network, we are faced with the problem of how to handle continuous variables. Most previous work has either solved the problem by discretizing, or assumed that the data are generated by a single Gaussian. In this paper we abandon the normality assumption and instead use statistical methods for nonparametric density estimation. For a naive Bayesian classifier, we present experimental results on a variety of natural and artificial domains, comparing two methods of density estimation: assuming normality and modeling each conditional distribution with a single Gaussian; and using nonparametric kernel density estimation. We observe large reductions in error on several natural and artificial data sets, which suggests that kernel estimation is a useful tool for learning Bayesian models. In Proceedings of the Eleventh Conference on Uncertainty in Artificial Intelligence, Morgan Kaufmann Publishers, San Mateo, 1995 1 Introduction In rec...