In this paper 1 we argue for the possibilities of applying the concept of autopoiesis to the information systems of modern organizations. Modern organizations in today’s rapidly changing, turbulent and complex environment are virtual, open, heterarchic and autopoietic. The main question we try to address in this paper is how to support these organizations with an adequate information system. We show that it is possible to develop autopoietic information systems that should be able to respond to the challenges of modern organizations.