Smullyan's notion of effectively inseparable pairs of sets is not the best effective /constructive analog of Kleene's notion of pairs of sets inseparable by a recursive set. We present a corrected notion of effectively inseparable pairs of sets, prove a characterization of our notion, and show that the pairs of index sets effectively inseparable in Smullyan's sense are the same as those effectively inseparable in ours. In fact we characterize the pairs of index sets effectively inseparable in either sense thereby generalizing Rice's Theorem. For subrecursive index sets we have sufficient conditions for various inseparabilities to hold. For inseparability by sets in the same subrecursive class we have a characterization. The latter essentially generalizes Kozen's (and Royer's later) Subrecursive Rice Theorem, and the proof of each result about subrecursive index sets is presented "Rogers style" with care to observe subrecursive restrictions. There are pairs of sets effectively inseparab...