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181
Unified segmentation
, 2005
"... A probabilistic framework is presented that enables image registration, tissue classification, and bias correction to be combined within the same generative model. A derivation of a loglikelihood objective function for the unified model is provided. The model is based on a mixture of Gaussians and ..."
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Cited by 324 (12 self)
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A probabilistic framework is presented that enables image registration, tissue classification, and bias correction to be combined within the same generative model. A derivation of a loglikelihood objective function for the unified model is provided. The model is based on a mixture of Gaussians and is extended to incorporate a smooth intensity variation and nonlinear registration with tissue probability maps. A strategy for optimising the model parameters is described, along with the requisite partial derivatives of the objective function.
Automated Manifold Surgery: Constructing Geometrically Accurate and Topologically Correct Models of the Human Cerebral Cortex
, 2001
"... Highly accurate surface models of the cerebral cortex are becoming increasingly important as tools in the investigation of the functional organization of the human brain. The construction of such models is difficult using current neuroimaging technology due to the high degree of cortical folding. E ..."
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Cited by 167 (25 self)
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Highly accurate surface models of the cerebral cortex are becoming increasingly important as tools in the investigation of the functional organization of the human brain. The construction of such models is difficult using current neuroimaging technology due to the high degree of cortical folding. Even single voxel misclassifications can result in erroneous connections being created between adjacent banks of a sulcus, resulting in a topologically inaccurate model. These topological defects cause the cortical model to no longer be homeomorphic to a sheet, preventing the accurate inflation, flattening, or spherical morphing of the reconstructed cortex. Surface deformation techniques can guarantee the topological correctness of a model, but are timeconsuming and may result in geometrically inaccurate models. In order to address this need we have developed a technique for taking a model of the cortex, detecting and fixing the topological defects while leaving that majority of the model intact, resulting in a surface that is both geometrically accurate and topologically correct.
A hybrid approach to the skull stripping problem in MRI
 NeuroImage
, 2004
"... We present a novel skullstripping algorithm based on a hybrid approach that combines watershed algorithms and deformable surface models. Our method takes advantage of the robustness of the former as well as the surface information available to the latter. The algorithm first localizes a single whit ..."
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Cited by 127 (11 self)
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We present a novel skullstripping algorithm based on a hybrid approach that combines watershed algorithms and deformable surface models. Our method takes advantage of the robustness of the former as well as the surface information available to the latter. The algorithm first localizes a single white matter voxel in a T1weighted MRI image, and uses it to create a global minimum in the white matter before applying a watershed algorithm with a preflooding height. The watershed algorithm builds an initial estimate of the brain volume based on the threedimensional connectivity of the white matter. This first step is robust, and performs well in the presence of intensity nonuniformities and noise, but may erode parts of the cortex that abut bright nonbrain structures such as the eye sockets, or may remove parts of the cerebellum. To correct these inaccuracies, a surface deformation process fits a smooth surface to the masked volume, allowing the incorporation of geometric constraints into the skullstripping procedure. A statistical atlas, generated from a set of accurately segmented brains, is used to validate and potentially correct the segmentation, and the MRI intensity values are locally reestimated at the boundary of the brain. Finally, a highresolution surface deformation is performed that accurately matches the outer boundary of the brain, resulting in a robust and automated procedure. Studies by our group and others outperform other publicly available skullstripping tools.
Smallworld anatomical networks in the human brain revealed by cortical thickness from MRI. Cerebral Cortex. Advance access published online January 4
, 2007
"... An important issue in neuroscience is the characterization for the underlying architectures of complex brain networks. However, little is known about the network of anatomical connections in the human brain. Here, we investigated largescale anatomical connection patterns of the human cerebral corte ..."
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Cited by 111 (10 self)
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An important issue in neuroscience is the characterization for the underlying architectures of complex brain networks. However, little is known about the network of anatomical connections in the human brain. Here, we investigated largescale anatomical connection patterns of the human cerebral cortex using cortical thickness measurements from magnetic resonance images. Two areas were considered anatomically connected if they showed statistically significant correlations in cortical thickness and we constructed the network of such connections using 124 brains from the International Consortium for Brain Mapping database. Significant short and longrange connections were found in both intra and interhemispheric regions, many of which were consistent with known neuroanatomical pathways measured by human diffusion imaging. More importantly, we showed that the human brain anatomical network had robust smallworld properties with cohesive neighborhoods and short mean distances between regions that were insensitive to the selection of correlation thresholds. Additionally, we also found that this network and the probability of finding a connection between 2 regions for a given anatomical distance had both exponentially truncated powerlaw distributions. Our results demonstrated the basic organizational principles for the anatomical network in the human brain compatible with previous functional networks studies, which provides important implications of how functional brain states originate from their structural underpinnings. To our knowledge, this study provides the first report of smallworld properties and degree distribution of anatomical networks in the human brain using cortical thickness measurements.
DeformationBased Surface Morphometry Applied to Gray Matter Deformation
, 2003
"... We present a unified statistical approach to deformationbased morphometry applied to the cortical surface. The cerebral cortex has the topology of a 2D highly convoluted sheet. As the brain develops over time, the cortical surface area, thickness, curvature and total gray matter volume change. It i ..."
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Cited by 80 (32 self)
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We present a unified statistical approach to deformationbased morphometry applied to the cortical surface. The cerebral cortex has the topology of a 2D highly convoluted sheet. As the brain develops over time, the cortical surface area, thickness, curvature and total gray matter volume change. It is highly likely that such agerelated surface changes are not uniform. By measuring how such surface metrics change over time, the regions of the most rapid structural changes can be localized. We avoided using surface flattening, which distorts the inherent geometry of the cortex in our analysis and it is only used in visualization. To increase the signal to noise ratio, di#usion smoothing, which generalizes Gaussian kernel smoothing to an arbitrary curved cortical surface, has been developed and applied to surface data. Afterwards, statistical inference on the cortical surface will be performed via random fields theory. As an illustration, we demonstrate how this new surfacebased morphometry can be applied in localizing the cortical regions of the gray matter tissue growth and loss in the brain images longitudinally collected in the group of children and adolescents.
Topology correction in brain cortex segmentation using a multiscale, graphbased algorithm
 IEEE Trans. Med. Imaging
, 2002
"... Abstract — Reconstructing an accurate and topologically correct representation of the cortical surface of the brain is an important objective in various neuroscience applications. Most cortical surface reconstruction methods either ignore topology or correct it using manual editing or methods that l ..."
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Cited by 66 (7 self)
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Abstract — Reconstructing an accurate and topologically correct representation of the cortical surface of the brain is an important objective in various neuroscience applications. Most cortical surface reconstruction methods either ignore topology or correct it using manual editing or methods that lead to inaccurate reconstructions. Shattuck and Leahy recently reported a fullyautomatic method that yields a topologically correct representation with little distortion of the underlying segmentation. We provide an alternate approach that has several advantages over their approach, including the use of arbitrary digital connectivities, a flexible morphologybased multiscale approach, and the option of foregroundonly or backgroundonly correction. A detailed analysis of the method's performance on 15 magnetic resonance brain images is provided.
Cortical thickness analysis in autism with heat kernel smoothing
 NeuroImage
, 2005
"... We present a novel data smoothing and analysis framework for cortical thickness data defined on the brain cortical manifold. Gaussian kernel smoothing, which weights neighboring observations according to their 3D Euclidean distance, has been widely used in 3D brain images to increase the signalton ..."
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Cited by 65 (23 self)
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We present a novel data smoothing and analysis framework for cortical thickness data defined on the brain cortical manifold. Gaussian kernel smoothing, which weights neighboring observations according to their 3D Euclidean distance, has been widely used in 3D brain images to increase the signaltonoise ratio. When the observations lie on a convoluted brain surface, however, it is more natural to assign the weights based on the geodesic distance along the surface. We therefore develop a framework for geodesic distancebased kernel smoothing and statistical analysis on the cortical manifolds. As an illustration, we apply our methods in detecting the regions of abnormal cortical thickness in 16 high functioning autistic children via random field based multiple comparison correction that utilizes the new smoothing technique.
A Fully Automatic and Robust Brain MRI Tissue Classification Method
 MEDICAL IMAGE ANALYSIS
, 2003
"... A novel, fully automatic, adaptive, robust procedure for brain tissue classification from 3D magnetic resonance head images (MRI) is described in this paper. The procedure is adaptive in that it customizes a training set, by using a "pruning" strategy, such that the classification is robus ..."
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Cited by 61 (1 self)
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A novel, fully automatic, adaptive, robust procedure for brain tissue classification from 3D magnetic resonance head images (MRI) is described in this paper. The procedure is adaptive in that it customizes a training set, by using a "pruning" strategy, such that the classification is robust against anatomical variability and pathology. Starting from a set of samples generated from prior tissue probability maps (a "model") in a standard, brainbased coordinate system ("stereotaxic space"), the method first reduces the fraction of incorrectly labeled samples in this set by using a minimum spanning tree graphtheoretic approach. Then, the corrected set of samples is used by a supervised kNN classifier for classifying the entire 3D image. The classification procedure is robust against variability in the image quality through a nonparametric implementation: no assumptions are made about the tissue intensity distributions. The performance of this brain tissue classification procedure is demonstrated through quantitative and qualitative validation experiments on both simulated MRI data (10 subjects) and real MRI data (43 subjects). A significant improvement in output quality was observed on subjects who exhibit morphological deviations from the model due to aging and pathology.
Fast and robust parameter estimation for statistical partial volume models in brain MRI
 NEUROIMAGE
, 2004
"... Due to the finite spatial resolution of imaging devices, a single voxel in a medical image may be composed of mixture of tissue types, an effect known as partial volume effect (PVE). Partial volume estimation, that is, the estimation of the amount of each tissue type within each voxel, has received ..."
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Cited by 54 (11 self)
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Due to the finite spatial resolution of imaging devices, a single voxel in a medical image may be composed of mixture of tissue types, an effect known as partial volume effect (PVE). Partial volume estimation, that is, the estimation of the amount of each tissue type within each voxel, has received considerable interest in recent years. Much of this work has been focused on the mixel model, a statistical model of PVE. We propose a novel trimmed minimum covariance determinant (TMCD) method for the estimation of the parameters of the mixel PVE model. In this method, each voxel is first labeled according to the most dominant tissue type. Voxels that are prone to PVE are removed from this labeled set, following which robust location estimators with high breakdown points are used to estimate the mean and the covariance of each tissue class. Comparisons between different methods for parameter estimation based on classified images as well as expectation–maximizationlike (EMlike) procedure for simultaneous parameter and
Geometrically Accurate TopologyCorrection of Cortical Surfaces Using Nonseparating Loops
, 2007
"... In this paper, we focus on the retrospective topology correction of surfaces. We propose a technique to accurately correct the spherical topology of cortical surfaces. Specifically, we construct a mapping from the original surface onto the sphere to detect topological defects as minimal nonhomeomor ..."
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Cited by 51 (5 self)
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In this paper, we focus on the retrospective topology correction of surfaces. We propose a technique to accurately correct the spherical topology of cortical surfaces. Specifically, we construct a mapping from the original surface onto the sphere to detect topological defects as minimal nonhomeomorphic regions. The topology of each defect is then corrected by opening and sealing the surface along a set of nonseparating loops that are selected in a Bayesian framework. The proposed method is a wholly selfcontained topology correction algorithm, which determines geometrically accurate, topologically correct solutions based on the magnetic resonance imaging (MRI) intensity profile and the expected local curvature. Applied to real data, our method provides topological corrections similar to those made by a trained operator.