Survival analysis is concerned with finding models to predict the survival of patients or to assess the efficacy of a clinical treatment. A key part of the model-building process is the selection of the predictor variables. It is standard to use a stepwise procedure guided by a series of significance tests to select a single model, and then to make inference conditionally on the selected model. However, this ignores model uncertainty, which can be substantial. We review the standard Bayesian model averaging solution to this problem and extend it to survival analysis, introducing partial Bayes factors to do so for the Cox proportional hazards model. In two examples, taking account of model uncertainty enhances predictive performance, to an extent that could be clinically useful. 1 Introduction From 1974 to 1984 the Mayo Clinic conducted a double-blinded randomized clinical trial involving 312 patients to compare the drug DPCA with a placebo in the treatment of primary biliary cirrhosis...

Elicitation is a key task for subjectivist Bayesians. While skeptics hold that it cannot (or perhaps should not) be done, in practice it brings statisticians closer to their clients and subjectmatter-expert colleagues. This paper reviews the state-of-the-art, reflecting the experience of statisticians informed by the fruits of a long line of psychological research into how people represent uncertain information cognitively, and how they respond to questions about that information. In a discussion of the elicitation process, the first issue to address is what it means for an elicitation to be successful, i.e. what criteria should be employed? Our answer is that a successful elicitation faithfully represents the opinion of the person being elicited. It is not necessarily “true ” in some objectivistic sense, and cannot be judged that way. We see elicitation as simply part of the process of statistical modeling. Indeed in a hierarchical model it is ambiguous at which point the likelihood ends and the prior begins. Thus the same kinds of judgment that inform statistical modeling in general also inform elicitation of prior distributions.

Both knowledge-based systems and statistical models are typically concerned with making predictions about future observables. Here we focus on assessment of predictive performance and provide two techniques for improving the predictive performance of Bayesian graphical models. First, we present Bayesian model averaging, a technique for accounting for model uncertainty. Second, we describe a technique for eliciting a prior distribution for competing models from domain experts. We explore the predictive performance of both techniques in the context of a urological diagnostic problem. KEYWORDS: Prediction; Bayesian graphical model; Bayesian network; Decomposable model; Model uncertainty; Elicitation. 1 Introduction Both statistical methods and knowledge-based systems are typically concerned with combining information from various sources to make inferences about prospective measurements. Inevitably, to combine information, we must make modeling assumptions. It follows that we should car...

Elicitation is a key task for subjectivist Bayesians. While skeptics hold that it cannot (or perhaps should not) be done, in practice it brings statisticians closer to their clients and subjectmatter-expert colleagues. This paper reviews the state-of-the-art, reflecting both the experience of statisticians and the fruits of a long line of psychological research into how people represent uncertain information cognitively, and how they respond to questions about that information. In a discussion of the elicitation process, the first issue to address is what it means for an elicitation to be successful, i.e. what criteria should be employed? Our answer is that a successful elicitation faithfully represents the opinion of the person being elicited. It is not necessarily “true ” in some objectivistic sense, and cannot be judged that way. We see elicitation as simply part of the process of statistical modeling. Indeed in a hierarchical model it is ambiguous at which point the likelihood ends and the prior begins. Thus the same kinds of judgment that inform statistical modeling in general also inform elicitation of prior distributions.