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...fying assumptions and empirical priors (David and Friston, 2003; Freeman, 1978; Lopes da Silva et al., 1974; Robinson et al., 2001; Stam et al., 1999; Valdes et al., 1999; Van Rotterdam et al., 1982; =-=Wendling et al., 2000-=-). The primary aim of this paper is to describe a candidate forward model and establish its face validity. This model was designed to reproduce responses seen empirically and enable mechanistic enquir...

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... brain structures. Starting from aforementioned works (part V), a canonical form of this class of models [Fig. 3(a)] representing a cluster of neurons containing three interacting subsets was studied =-=[125]-=-. The first subset is composed of the main cells (i.e., pyramidal cells in the hippocampus or neocortex). It receives feedback from the two other subsets composed of local inhibitory interneurons and ...

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...respond to a distinct cortical neuronal population. Its time course, which represents the time-varying dynamics of the associated population, was provided by the output of a neuronal population model =-=[54]-=-, in which parameters can be adjusted to generate either background-like activity or interictal-spikes. In this model the source of these epileptic activities was manually delineated on the mesh as a ...

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...a number of patches each of which consists of 100 adjacent grid dipoles corresponding to a cortical area of approximately 5 cm2. Using a model of coupled neuronal populations as previously described (=-=Wendling et al., 2000-=-; Cosandier-Rimélé et al., 2007; Cosandier-Rimélé et al., 2010), 14 highly-correlated epileptiform spike-like signals comprising Nt = 200 time samples with a sampling rate of 256 Hz are created fo...

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...tory effects related to GABAb receptors present on the presynaptic membrane (Bailey et al. 2004; Deisz et al. 1997). Another perspective will be to connect the hippocampus model previously developed (=-=Wendling et al. 2000-=-, 2002) with the present EC model to obtain a more complete model of the hippocampus–EC loop. In this model extension, we will probably also need to represent the dentate gyrus and the subiculum becau...

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...m in the dog’s EEG (Lopes da Silva et al., 1974, 1976), and has now firmly demonstrated its ability to capture the dynamics of cortical areas (Zetterberg et al., 1978; Suffczynski et al., 2001, 2006; =-=Wendling et al., 2000-=-, 2002). The question of what makes a good neural mass model is far reaching, and the answer clearly depends on the phenomena one wants to account for. Even for single neuron models, the question is s...

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...ysiological data interpretation were reported by Freeman [20] and LopessDa Silva [21, 22]. More recently, this class of models was exploited in varioussneurophysiological or clinical studies [23, 24] =-=[16, 25]-=- [26] .sThis macroscopic approach differs from Traub’s [15] which uses a large number (up to moresthan one thousand) of neurons and interneurons (each one represented by a complex multiscompartmental ...