Abstract. This paper introduces a new similarity measure for multimodal image registration task. The measure is based on the generalized survival exponential entropy (GSEE) and mutual information (GSEE-MI). Since GSEE is estimated from the cumulative distribution function instead of the density function, it is observed that the interpolation artifact is reduced. The method has been tested on four real MR-CT data sets. The experimental results show that the GSEE-MI-based method is more robust than the conventional MI-based method. The accuracy is comparable for both methods. 1

In this paper, we propose a novel and robust algorithm for the groupwise non-rigid registration of multiple unlabeled point-sets with no bias toward any of the given pointsets. To quantify the divergence between multiple probability distributions each estimated from the given point sets, we develop a novel measure based on their cumulative distribution functions that we dub the CDF-JS divergence. The measure parallels the well known Jensen-Shannon divergence (defined for probability density functions) but is more regular than the JS divergence since its definition is based on CDFs as opposed to density functions. As a consequence, CDF-JS is more immune to noise and statistically more robust than the JS. We derive the analytic gradient of the CDF-JS divergence

Abstract. In this paper, we present a novel variational formulation of the registration assisted image segmentation problem which leads to solving a coupled set of nonlinear PDEs that are solved using efficient numerical schemes. Our work is a departure from earlier methods in that we have a unified variational principle wherein non-rigid registration and segmentation are simultaneously achieved; unlike previous methods of solution for this problem, our algorithm can accommodate for image pairs having very distinct intensity distributions. We present examples of performance of our algorithm on synthetic and real data sets along with quantitative accuracy estimates of the registration. 1