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Discriminating imagined from perceived information engages brain areas implicated in schizophrenia
- Neuroimage
, 2006
"... Some of the symptoms of schizophrenia may reflect a difficulty discriminating between information that was perceived from the outside world and information that was imagined. This study used fMRI to examine the brain regions associated with this reality monitoring ability in healthy volunteers, who ..."
Abstract
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Cited by 12 (2 self)
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Some of the symptoms of schizophrenia may reflect a difficulty discriminating between information that was perceived from the outside world and information that was imagined. This study used fMRI to examine the brain regions associated with this reality monitoring ability in healthy volunteers, who recollected whether information had previously been perceived or imagined, or whether information had been presented on the left or right of a monitor screen. Recent studies have suggested that schizophrenia may be associated particularly with dysfunction in medial anterior prefrontal cortex, thalamus, and cerebellum. In our data, activation in all three of these regions of interest was significantly greater during recollection of whether stimuli had been perceived or imagined versus recollection of stimulus position. In addition, reduced prefrontal activation was associated with the same misattribution error that has been observed in schizophrenia. These results indicate a possible link between the brain areas implicated in schizophrenia and the regions supporting the ability to discriminate between perceived and imagined information. D
ck
, 2005
"... studies based on positron emission tomography (PET) in which response modulations necessarily had to be measured over a of extant studies, have been attributed to transient mismatch between neuronal metabolic demand (assumed to be constant different task conditions: 2-back working memory, visual sce ..."
Abstract
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studies based on positron emission tomography (PET) in which response modulations necessarily had to be measured over a of extant studies, have been attributed to transient mismatch between neuronal metabolic demand (assumed to be constant different task conditions: 2-back working memory, visual scene analysis, overt word reading, and simple visual fixation. We Block design fMRI involves administering blocks of contrast-ing experimental conditions, for example task vs. rest, over epochs typically 25–40 s in duration. Conventionally, block design analyses evaluate signal modulation attributable to condition
RESTING STATE CONNECTIVITY IN THE RAT BRAIN
, 2006
"... work could not have been completed without the assistance and input ..."
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