This un-edited manuscript has been accepted for publication in Biophysical Journal and is freely available on BioFAST at www.biophysj.org. The final copyedited version of the paper may be found at www.biophysj.org.

The more we know about the molecular biology of the cell, the more we see genes and proteins as part of networks or pathways instead of as isolated entities and understand their function as a variable of the cellular context. To fulfill this new paradigm, genomic sequences offer a catalog of building blocks, and protein interactions provide the first information for