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Comparison of discrimination methods for the classification of tumors using gene expression data
 JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
, 2002
"... A reliable and precise classification of tumors is essential for successful diagnosis and treatment of cancer. cDNA microarrays and highdensity oligonucleotide chips are novel biotechnologies increasingly used in cancer research. By allowing the monitoring of expression levels in cells for thousand ..."
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Cited by 774 (6 self)
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A reliable and precise classification of tumors is essential for successful diagnosis and treatment of cancer. cDNA microarrays and highdensity oligonucleotide chips are novel biotechnologies increasingly used in cancer research. By allowing the monitoring of expression levels in cells for thousands of genes simultaneously, microarray experiments may lead to a more complete understanding of the molecular variations among tumors and hence to a finer and more informative classification. The ability to successfully distinguish between tumor classes (already known or yet to be discovered) using gene expression data is an important aspect of this novel approach to cancer classification. This article compares the performance of different discrimination methods for the classification of tumors based on gene expression data. The methods include nearestneighbor classifiers, linear discriminant analysis, and classification trees. Recent machine learning approaches, such as bagging and boosting, are also considered. The discrimination methods are applied to datasets from three recently published cancer gene expression studies.
General methods for monitoring convergence of iterative simulations
 J. Comput. Graph. Statist
, 1998
"... We generalize the method proposed by Gelman and Rubin (1992a) for monitoring the convergence of iterative simulations by comparing between and within variances of multiple chains, in order to obtain a family of tests for convergence. We review methods of inference from simulations in order to develo ..."
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Cited by 532 (8 self)
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We generalize the method proposed by Gelman and Rubin (1992a) for monitoring the convergence of iterative simulations by comparing between and within variances of multiple chains, in order to obtain a family of tests for convergence. We review methods of inference from simulations in order to develop convergencemonitoring summaries that are relevant for the purposes for which the simulations are used. We recommend applying a battery of tests for mixing based on the comparison of inferences from individual sequences and from the mixture of sequences. Finally, we discuss multivariate analogues, for assessing convergence of several parameters simultaneously.
On the distribution of the largest eigenvalue in principal components analysis
 Ann. Statist
, 2001
"... Let x �1 � denote the square of the largest singular value of an n × p matrix X, all of whose entries are independent standard Gaussian variates. Equivalently, x �1 � is the largest principal component variance of the covariance matrix X ′ X, or the largest eigenvalue of a pvariate Wishart distribu ..."
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Cited by 421 (4 self)
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Let x �1 � denote the square of the largest singular value of an n × p matrix X, all of whose entries are independent standard Gaussian variates. Equivalently, x �1 � is the largest principal component variance of the covariance matrix X ′ X, or the largest eigenvalue of a pvariate Wishart distribution on n degrees of freedom with identity covariance. Consider the limit of large p and n with n/p = γ ≥ 1. When centered by µ p = � √ n − 1 + √ p � 2 and scaled by σ p = � √ n − 1 + √ p��1 / √ n − 1 + 1 / √ p � 1/3 � the distribution of x �1 � approaches the Tracy–Widom lawof order 1, which is defined in terms of the Painlevé II differential equation and can be numerically evaluated and tabulated in software. Simulations showthe approximation to be informative for n and p as small as 5. The limit is derived via a corresponding result for complex Wishart matrices using methods from random matrix theory. The result suggests that some aspects of large p multivariate distribution theory may be easier to apply in practice than their fixed p counterparts. 1. Introduction. The
Survey of clustering data mining techniques
, 2002
"... Accrue Software, Inc. Clustering is a division of data into groups of similar objects. Representing the data by fewer clusters necessarily loses certain fine details, but achieves simplification. It models data by its clusters. Data modeling puts clustering in a historical perspective rooted in math ..."
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Cited by 400 (0 self)
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Accrue Software, Inc. Clustering is a division of data into groups of similar objects. Representing the data by fewer clusters necessarily loses certain fine details, but achieves simplification. It models data by its clusters. Data modeling puts clustering in a historical perspective rooted in mathematics, statistics, and numerical analysis. From a machine learning perspective clusters correspond to hidden patterns, the search for clusters is unsupervised learning, and the resulting system represents a data concept. From a practical perspective clustering plays an outstanding role in data mining applications such as scientific data exploration, information retrieval and text mining, spatial database applications, Web analysis, CRM, marketing, medical diagnostics, computational biology, and many others. Clustering is the subject of active research in several fields such as statistics, pattern recognition, and machine learning. This survey focuses on clustering in data mining. Data mining adds to clustering the complications of very large datasets with very many attributes of different types. This imposes unique
Sliced inverse regression for dimension reduction
 J. AMER. STATIST. ASSOC
, 1991
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GTM: The generative topographic mapping
 Neural Computation
, 1998
"... Latent variable models represent the probability density of data in a space of several dimensions in terms of a smaller number of latent, or hidden, variables. A familiar example is factor analysis which is based on a linear transformations between the latent space and the data space. In this paper ..."
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Cited by 359 (7 self)
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Latent variable models represent the probability density of data in a space of several dimensions in terms of a smaller number of latent, or hidden, variables. A familiar example is factor analysis which is based on a linear transformations between the latent space and the data space. In this paper we introduce a form of nonlinear latent variable model called the Generative Topographic Mapping for which the parameters of the model can be determined using the EM algorithm. GTM provides a principled alternative to the widely used SelfOrganizing Map (SOM) of Kohonen (1982), and overcomes most of the significant limitations of the SOM. We demonstrate the performance of the GTM algorithm on a toy problem and on simulated data from flow diagnostics for a multiphase oil pipeline. Copyright c○MIT Press (1998). 1
The Conservatism Principle and the Asymmetric Timeliness of Earnings
 Journal of Accounting and Economics
, 1997
"... I interpret conservatism as resulting in earnings reflecting 'bad news ' more quickly than 'good news'. This interpretation implies systematic differences between bad news and good news periods in the timeliness and persistence of earnings. Using firms ' stock returns to mea ..."
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Cited by 342 (1 self)
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I interpret conservatism as resulting in earnings reflecting 'bad news ' more quickly than 'good news'. This interpretation implies systematic differences between bad news and good news periods in the timeliness and persistence of earnings. Using firms ' stock returns to measure news, the contemporaneous sensitivity of earnings to negative returns is two to six times that of earnings to positive returns. I also predict and find that negative earnings changes are less persistent than positive earnings changes. Earnings response coefficients (ERCs) are higher for positive earnings changes than for negative arnings
Visualizing data using tSNE
 Costsensitive Machine Learning for Information Retrieval 33
"... We present a new technique called “tSNE ” that visualizes highdimensional data by giving each datapoint a location in a two or threedimensional map. The technique is a variation of Stochastic Neighbor Embedding (Hinton and Roweis, 2002) that is much easier to optimize, and produces significantly ..."
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Cited by 273 (11 self)
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We present a new technique called “tSNE ” that visualizes highdimensional data by giving each datapoint a location in a two or threedimensional map. The technique is a variation of Stochastic Neighbor Embedding (Hinton and Roweis, 2002) that is much easier to optimize, and produces significantly better visualizations by reducing the tendency to crowd points together in the center of the map. tSNE is better than existing techniques at creating a single map that reveals structure at many different scales. This is particularly important for highdimensional data that lie on several different, but related, lowdimensional manifolds, such as images of objects from multiple classes seen from multiple viewpoints. For visualizing the structure of very large data sets, we show how tSNE can use random walks on neighborhood graphs to allow the implicit structure of all of the data to influence the way in which a subset of the data is displayed. We illustrate the performance of tSNE on a wide variety of data sets and compare it with many other nonparametric visualization techniques, including Sammon mapping, Isomap, and Locally Linear Embedding. The visualizations produced by tSNE are significantly better than those produced by the other techniques on almost all of the data sets.
Sparse Principal Component Analysis
 Journal of Computational and Graphical Statistics
, 2004
"... Principal component analysis (PCA) is widely used in data processing and dimensionality reduction. However, PCA su#ers from the fact that each principal component is a linear combination of all the original variables, thus it is often di#cult to interpret the results. We introduce a new method ca ..."
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Cited by 272 (6 self)
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Principal component analysis (PCA) is widely used in data processing and dimensionality reduction. However, PCA su#ers from the fact that each principal component is a linear combination of all the original variables, thus it is often di#cult to interpret the results. We introduce a new method called sparse principal component analysis (SPCA) using the lasso (elastic net) to produce modified principal components with sparse loadings. We show that PCA can be formulated as a regressiontype optimization problem, then sparse loadings are obtained by imposing the lasso (elastic net) constraint on the regression coe#cients. E#cient algorithms are proposed to realize SPCA for both regular multivariate data and gene expression arrays. We also give a new formula to compute the total variance of modified principal components. As illustrations, SPCA is applied to real and simulated data, and the results are encouraging.
Applications of Resampling Methods to Estimate the Number of Clusters and to Improve the Accuracy of a Clustering Method
, 2001
"... The burgeoning field of genomics, and in particular microarray experiments, have revived interest in both discriminant and cluster analysis, by raising new methodological and computational challenges. The present paper discusses applications of resampling methods to problems in cluster analysis. A r ..."
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Cited by 235 (0 self)
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The burgeoning field of genomics, and in particular microarray experiments, have revived interest in both discriminant and cluster analysis, by raising new methodological and computational challenges. The present paper discusses applications of resampling methods to problems in cluster analysis. A resampling method, known as bagging in discriminant analysis, is applied to increase clustering accuracy and to assess the confidence of cluster assignments for individual observations. A novel predictionbased resampling method is also proposed to estimate the number of clusters, if any, in a dataset. The performance of the proposed and existing methods are compared using simulated data and gene expression data from four recently published cancer microarray studies.