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Genetic Programming
, 1997
"... Introduction Genetic programming is a domainindependent problemsolving approach in which computer programs are evolved to solve, or approximately solve, problems. Genetic programming is based on the Darwinian principle of reproduction and survival of the fittest and analogs of naturally occurring ..."
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Cited by 1019 (12 self)
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Introduction Genetic programming is a domainindependent problemsolving approach in which computer programs are evolved to solve, or approximately solve, problems. Genetic programming is based on the Darwinian principle of reproduction and survival of the fittest and analogs of naturally occurring genetic operations such as crossover (sexual recombination) and mutation. John Holland's pioneering Adaptation in Natural and Artificial Systems (1975) described how an analog of the evolutionary process can be applied to solving mathematical problems and engineering optimization problems using what is now called the genetic algorithm (GA). The genetic algorithm attempts to find a good (or best) solution to the problem by genetically breeding a population of individuals over a series of generations. In the genetic algorithm, each individual in the population represents a candidate solut
The Advantages of Evolutionary Computation
, 1997
"... Evolutionary computation is becoming common in the solution of difficult, realworld problems in industry, medicine, and defense. This paper reviews some of the practical advantages to using evolutionary algorithms as compared with classic methods of optimization or artificial intelligence. Specific ..."
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Cited by 485 (5 self)
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Evolutionary computation is becoming common in the solution of difficult, realworld problems in industry, medicine, and defense. This paper reviews some of the practical advantages to using evolutionary algorithms as compared with classic methods of optimization or artificial intelligence. Specific advantages include the flexibility of the procedures, as well as the ability to selfadapt the search for optimum solutions on the fly. As desktop computers increase in speed, the application of evolutionary algorithms will become routine. 1 Introduction Darwinian evolution is intrinsically a robust search and optimization mechanism. Evolved biota demonstrate optimized complex behavior at every level: the cell, the organ, the individual, and the population. The problems that biological species have solved are typified by chaos, chance, temporality, and nonlinear interactivities. These are also characteristics of problems that have proved to be especially intractable to classic methods of o...
Multiobjective Evolutionary Algorithms: Analyzing the StateoftheArt
, 2000
"... Solving optimization problems with multiple (often conflicting) objectives is, generally, a very difficult goal. Evolutionary algorithms (EAs) were initially extended and applied during the mideighties in an attempt to stochastically solve problems of this generic class. During the past decade, ..."
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Cited by 385 (7 self)
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Solving optimization problems with multiple (often conflicting) objectives is, generally, a very difficult goal. Evolutionary algorithms (EAs) were initially extended and applied during the mideighties in an attempt to stochastically solve problems of this generic class. During the past decade, a variety of multiobjective EA (MOEA) techniques have been proposed and applied to many scientific and engineering applications. Our discussion's intent is to rigorously define multiobjective optimization problems and certain related concepts, present an MOEA classification scheme, and evaluate the variety of contemporary MOEAs. Current MOEA theoretical developments are evaluated; specific topics addressed include fitness functions, Pareto ranking, niching, fitness sharing, mating restriction, and secondary populations. Since the development and application of MOEAs is a dynamic and rapidly growing activity, we focus on key analytical insights based upon critical MOEA evaluation of c...
A Genetic Algorithm Tutorial
 Statistics and Computing
, 1994
"... This tutorial covers the canonical genetic algorithm as well as more experimental forms of genetic algorithms, including parallel island models and parallel cellular genetic algorithms. The tutorial also illustrates genetic search byhyperplane sampling. The theoretical foundations of genetic algorit ..."
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Cited by 279 (5 self)
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This tutorial covers the canonical genetic algorithm as well as more experimental forms of genetic algorithms, including parallel island models and parallel cellular genetic algorithms. The tutorial also illustrates genetic search byhyperplane sampling. The theoretical foundations of genetic algorithms are reviewed, include the schema theorem as well as recently developed exact models of the canonical genetic algorithm.
Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function
 J. Comput. Chem
, 1998
"... ABSTRACT: A novel and robust automated docking method that predicts the bound conformations of flexible ligands to macromolecular targets has been developed and tested, in combination with a new scoring function that estimates the free energy change upon binding. Interestingly, this method applies a ..."
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Cited by 279 (4 self)
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ABSTRACT: A novel and robust automated docking method that predicts the bound conformations of flexible ligands to macromolecular targets has been developed and tested, in combination with a new scoring function that estimates the free energy change upon binding. Interestingly, this method applies a Lamarckian model of genetics, in which environmental adaptations of an individual’s phenotype are reverse transcribed into its genotype and become heritable traits Ž sic.. We consider three search methods, Monte Carlo simulated annealing, a traditional genetic algorithm, and the Lamarckian genetic algorithm, and compare their performance in dockings of seven protein�ligand test systems having known threedimensional structure. We show that both the traditional and Lamarckian genetic algorithms can handle ligands with more degrees of freedom than the simulated annealing method used in earlier versions of AUTODOCK, and that the Lamarckian genetic algorithm is the most efficient, reliable, and successful of the three. The empirical free energy function was calibrated using a set of 30 structurally known protein�ligand complexes with experimentally determined binding constants. Linear regression analysis of the observed binding constants in terms of a wide variety of structurederived molecular properties was performed. The final model had a residual standard �1 Ž �1 error of 9.11 kJ mol 2.177 kcal mol. and was chosen as the new energy
Evolutionary Algorithms for Constrained Parameter Optimization Problems
 Evolutionary Computation
, 1996
"... Evolutionary computation techniques have received a lot of attention regarding their potential as optimization techniques for complex numerical functions. However, they have not produced a significant breakthrough in the area of nonlinear programming due to the fact that they have not addressed the ..."
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Cited by 278 (19 self)
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Evolutionary computation techniques have received a lot of attention regarding their potential as optimization techniques for complex numerical functions. However, they have not produced a significant breakthrough in the area of nonlinear programming due to the fact that they have not addressed the issue of constraints in a systematic way. Only recently several methods have been proposed for handling nonlinear constraints by evolutionary algorithms for numerical optimization problems; however, these methods have several drawbacks and the experimental results on many test cases have been disappointing. In this paper we (1) discuss difficulties connected with solving the general nonlinear programming problem, (2) survey several approaches which have emerged in the evolutionary computation community, and (3) provide a set of eleven interesting test cases, which may serve as a handy reference for future methods. 1 Introduction The general nonlinear programming (NLP) problem is to find ~x ...
A Comprehensive Survey of EvolutionaryBased Multiobjective Optimization Techniques
 Knowledge and Information Systems
, 1998
"... . This paper presents a critical review of the most important evolutionarybased multiobjective optimization techniques developed over the years, emphasizing the importance of analyzing their Operations Research roots as a way to motivate the development of new approaches that exploit the search cap ..."
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Cited by 267 (22 self)
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. This paper presents a critical review of the most important evolutionarybased multiobjective optimization techniques developed over the years, emphasizing the importance of analyzing their Operations Research roots as a way to motivate the development of new approaches that exploit the search capabilities of evolutionary algorithms. Each technique is briefly described mentioning its advantages and disadvantages, their degree of applicability and some of their known applications. Finally, the future trends in this discipline and some of the open areas of research are also addressed. Keywords: multiobjective optimization, multicriteria optimization, vector optimization, genetic algorithms, evolutionary algorithms, artificial intelligence. 1 Introduction Since the pioneer work of Rosenberg in the late 60s regarding the possibility of using geneticbased search to deal with multiple objectives, this new area of research (now called evolutionary multiobjective optimization) has grown c...
Evolutionary computation: Comments on the history and current state
 IEEE TRANSACTIONS ON EVOLUTIONARY COMPUTATION
, 1997
"... Evolutionary computation has started to receive significant attention during the last decade, although the origins can be traced back to the late 1950’s. This article surveys the history as well as the current state of this rapidly growing field. We describe the purpose, the general structure, and ..."
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Cited by 261 (0 self)
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Evolutionary computation has started to receive significant attention during the last decade, although the origins can be traced back to the late 1950’s. This article surveys the history as well as the current state of this rapidly growing field. We describe the purpose, the general structure, and the working principles of different approaches, including genetic algorithms (GA) [with links to genetic programming (GP) and classifier systems (CS)], evolution strategies (ES), and evolutionary programming (EP) by analysis and comparison of their most important constituents (i.e., representations, variation operators, reproduction, and selection mechanism). Finally, we give a brief overview on the manifold of application domains, although this necessarily must remain incomplete.
Feature Subset Selection Using A Genetic Algorithm
, 1997
"... : Practical pattern classification and knowledge discovery problems require selection of a subset of attributes or features (from a much larger set) to represent the patterns to be classified. This is due to the fact that the performance of the classifier (usually induced by some learning algorithm) ..."
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Cited by 249 (7 self)
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: Practical pattern classification and knowledge discovery problems require selection of a subset of attributes or features (from a much larger set) to represent the patterns to be classified. This is due to the fact that the performance of the classifier (usually induced by some learning algorithm) and the cost of classification are sensitive to the choice of the features used to construct the classifier. Exhaustive evaluation of possible feature subsets is usually infeasible in practice because of the large amount of computational effort required. Genetic algorithms, which belong to a class of randomized heuristic search techniques, offer an attractive approach to find nearoptimal solutions to such optimization problems. This paper presents an approach to feature subset selection using a genetic algorithm. Some advantages of this approach include the ability to accommodate multiple criteria such as accuracy and cost of classification into the feature selection process and to find fe...