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Global stability of the endemic equilibrium of multigroup SIR epidemic models
, 2006
"... ABSTRACT. For a class of multigroup SIR epidemic models with varying subpopulation sizes, we establish that the global dynamics are completely determined by the basic reproduction number R0. More specifically, we prove that, if R0 ≤ 1, then the diseasefree equilibrium is globally asymptotically sta ..."
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ABSTRACT. For a class of multigroup SIR epidemic models with varying subpopulation sizes, we establish that the global dynamics are completely determined by the basic reproduction number R0. More specifically, we prove that, if R0 ≤ 1, then the diseasefree equilibrium is globally asymptotically stable; if R0> 1, then there exists a unique endemic equilibrium and it is globally asymptotically stable in the interior of the feasible region. Our proof of global stability utilizes the method of global Lyapunov functions and results from graph theory. 1 Introduction Multigroup models have been proposed in the literature to describe the transmission dynamics of infectious diseases in heterogeneous host populations. Heterogeneity in host population can be the result of many factors. Individual hosts can be divided into groups according to different contact patterns such as those among children and
Computing A DiameterConstrained Minimum Spanning Tree
, 2001
"... In numerous practical applications, it is necessary to find the smallest possible tree with a bounded diameter. A diameterconstrained minimum spanning tree (DCMST) of a given undirected, edgeweighted graph, G, is the smallestweight spanning tree of all spanning trees of G which contain no path wi ..."
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Cited by 10 (0 self)
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In numerous practical applications, it is necessary to find the smallest possible tree with a bounded diameter. A diameterconstrained minimum spanning tree (DCMST) of a given undirected, edgeweighted graph, G, is the smallestweight spanning tree of all spanning trees of G which contain no path with more than k edges, where k is a given positive integer. The problem of finding a DCMST is NPcomplete for all values of k; 4 k (n  2), except when all edgeweights are identical. A DCMST is essential for the efficiency of various distributed mutual exclusion algorithms, where it can minimize the number of messages communicated among processors per critical section. It is also useful in linear lightwave networks, where it can minimize interference in the network by limiting the traffic in the network lines. Another practical application requiring a DCMST arises in data compression, where some algorithms compress a file utilizing a tree datastructure, and decompress a path in the tree to access a record. A DCMST helps such algorithms to be fast without sacrificing a lot of storage space. We present a survey of the literature on the DCMST problem, study the expected diameter of a random labeled tree, and present five new polynomialtime algorithms for an approximate DCMST. One of our new algorithms constructs an approximate DCMST in a modified greedy fashion, employing a heuristic for selecting an edge to be added to iii the tree in each stage of the construction. Three other new algorithms start with an unconstrained minimum spanning tree, and iteratively refine it into an approximate DCMST. We also present an algorithm designed for the special case when the diameter is required to be no more than 4. Such a diameter4 tree is also used for evaluating the quality of o...
MODELS FOR INFECTIOUS DISEASES∗
"... Abstract. We propose a general class of multistage epidemiological models that allow possible deterioration and amelioration between any two infected stages. The models can describe disease progression through multiple latent or infectious stages as in the case of HIV and tuberculosis. Amelioration ..."
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Abstract. We propose a general class of multistage epidemiological models that allow possible deterioration and amelioration between any two infected stages. The models can describe disease progression through multiple latent or infectious stages as in the case of HIV and tuberculosis. Amelioration is incorporated into the models to account for the effects of antiretroviral or antibiotic treatment. The models also incorporate general nonlinear incidences and general nonlinear forms of population transfer among stages. Under biologically motivated assumptions, we derive the basic reproduction number R0 and show that the global dynamics are completely determined by R0: if R0 ≤ 1, the diseasefree equilibrium is globally asymptotically stable, and the disease dies out; if R0> 1, then the disease persists in all stages and a unique endemic equilibrium is globally asymptotically stable.