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Statistics and Causal Inference: A Review
, 2003
"... This paper aims at assisting empirical researchers benefit from recent advances in causal inference. The paper stresses the paradigmatic shifts that must be undertaken in moving from traditional statistical analysis to causal analysis of multivariate data. Special emphasis is placed on the assump ..."
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This paper aims at assisting empirical researchers benefit from recent advances in causal inference. The paper stresses the paradigmatic shifts that must be undertaken in moving from traditional statistical analysis to causal analysis of multivariate data. Special emphasis is placed on the assumptions that underly all causal inferences, the languages used in formulating those assumptions, and the conditional nature of causal claims inferred from nonexperimental studies. These emphases are illustrated through a brief survey of recent results, including the control of confounding, the assessment of causal effects, the interpretation of counterfactuals, and a symbiosis between counterfactual and graphical methods of analysis.
Yes, But What’s the Mechanism? (Don’t Expect an Easy Answer)
"... Psychologists increasingly recommend experimental analysis of mediation. This is a step in the right direction because mediation analyses based on nonexperimental data are likely to be biased and because experiments, in principle, provide a sound basis for causal inference. But even experiments cann ..."
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Psychologists increasingly recommend experimental analysis of mediation. This is a step in the right direction because mediation analyses based on nonexperimental data are likely to be biased and because experiments, in principle, provide a sound basis for causal inference. But even experiments cannot overcome certain threats to inference that arise chiefly or exclusively in the context of mediation analysis—threats that have received little attention in psychology. The authors describe 3 of these threats and suggest ways to improve the exposition and design of mediation tests. Their conclusion is that inference about mediators is far more difficult than previous research suggests and is best tackled by an experimental research program that is specifically designed to address the challenges of mediation analysis.
Transportability across studies: A formal approach
, 2010
"... We provide a formal definition of the notion of “transportability, ” or “external validity, ” which we view as a license to transfer causal information learned in experimental studies to a different environment, in which only observational studies can be conducted. We introduce a formal representati ..."
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We provide a formal definition of the notion of “transportability, ” or “external validity, ” which we view as a license to transfer causal information learned in experimental studies to a different environment, in which only observational studies can be conducted. We introduce a formal representation called “selection diagrams ” for expressing knowledge about differences and commonalities between populations of interest and, using this representation, we derive procedures for deciding whether causal effects in the target environment can be inferred from experimental findings in a different environment. When the answer is affirmative, the procedures identify the set of experimental and observational studies that need be conducted to license the transport. We further demonstrate how transportability analysis can guide the transfer of knowledge among nonexperimental studies to minimize remeasurement cost and improve prediction power. We further provide a causally principled definition of “surrogate endpoint ” and show that the theory of transportability can assist the identification of valid surrogates in a complex network of causeeffect relationships. 1 Introduction: Threats
Trygve Haavelmo and the Emergence of Causal Calculus
, 2012
"... Haavelmo was the first to recognize the capacity of economic models to guide policies. This paper describes some of the barriers that Haavelmo’s ideas have had (and still have) to overcome, and lays out a logical framework for capturing the relationships between theory, data and policy questions. Th ..."
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Haavelmo was the first to recognize the capacity of economic models to guide policies. This paper describes some of the barriers that Haavelmo’s ideas have had (and still have) to overcome, and lays out a logical framework for capturing the relationships between theory, data and policy questions. The mathematical tools that emerge from this framework now enable investigators to answer complex policy and counterfactual questions using embarrassingly simple routines, some by mere inspection of the model’s structure. Several such problems are illustrated by examples, including misspecification tests, identification, mediation and introspection. Finally, we observe that modern economists are largely unaware of the benefits that Haavelmo’s ideas bestow upon them and, as a result, econometric research has not fully utilized modern advances in causal analysis. 1
2007): “Defining and estimating intervention effects for groups that will develop an auxiliary outcome
 Statistical Science
"... Abstract. It has recently become popular to define treatment effects for subsets of the target population characterized by variables not observable at the time a treatment decision is made. Characterizing and estimating such treatment effects is tricky; the most popular but naive approach inappropri ..."
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Abstract. It has recently become popular to define treatment effects for subsets of the target population characterized by variables not observable at the time a treatment decision is made. Characterizing and estimating such treatment effects is tricky; the most popular but naive approach inappropriately adjusts for variables affected by treatment and so is biased. We consider several appropriate ways to formalize the effects: principal stratification, stratification on a single potential auxiliary variable, stratification on an observed auxiliary variable and stratification on expected levels of auxiliary variables. We then outline identifying assumptions for each type of estimand. We evaluate the utility of these estimands and estimation procedures for decision making and understanding causal processes, contrasting them with the concepts of direct and indirect effects. We motivate our development with examples from nephrology and cancer screening, and use simulated data and real data on cancer screening to illustrate the estimation methods. Key words and phrases: Causality, direct effects, interaction, effect modification, bias, principal stratification.
Direct and Indirect Effects of Sequential Treatments
 In: Proc. of the 22nd Conference on Uncertainty in Artificial Intelligence
, 2006
"... In this paper we review the notion of direct and indirect causal effect as introduced by Pearl (2001). We show how it can be formulated without counterfactuals, using regime indicators instead. This allows to consider the natural (in)direct effect as a special case of sequential treatments discussed ..."
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Cited by 7 (3 self)
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In this paper we review the notion of direct and indirect causal effect as introduced by Pearl (2001). We show how it can be formulated without counterfactuals, using regime indicators instead. This allows to consider the natural (in)direct effect as a special case of sequential treatments discussed by Dawid & Didelez (2005) which immediately yields conditions for identifiability as well as a graphical way of checking identifiability. 1
Complete Identification Methods for the Causal Hierarchy
"... We consider a hierarchy of queries about causal relationships in graphical models, where each level in the hierarchy requires more detailed information than the one below. The hierarchy consists of three levels: associative relationships, derived from a joint distribution over the observable variabl ..."
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We consider a hierarchy of queries about causal relationships in graphical models, where each level in the hierarchy requires more detailed information than the one below. The hierarchy consists of three levels: associative relationships, derived from a joint distribution over the observable variables; causeeffect relationships, derived from distributions resulting from external interventions; and counterfactuals, derived from distributions that span multiple “parallel worlds ” and resulting from simultaneous, possibly conflicting observations and interventions. We completely characterize cases where a given causal query can be computed from information lower in the hierarchy, and provide algorithms that accomplish this computation. Specifically, we show when effects of interventions can be computed from observational studies, and when probabilities of counterfactuals can be computed from experimental studies. We also provide a graphical characterization of those queries which cannot be computed (by any method) from queries at a lower layer of the hierarchy.
Transportability of Causal Effects: Completeness Results
, 2012
"... The study of transportability aims to identify conditions under which causal information learned from experiments can be reused in a different environment where only passive observations can be collected. The theory introduced in [Pearl and Bareinboim, 2011] (henceforth [PB, 2011]) defines formal co ..."
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Cited by 7 (4 self)
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The study of transportability aims to identify conditions under which causal information learned from experiments can be reused in a different environment where only passive observations can be collected. The theory introduced in [Pearl and Bareinboim, 2011] (henceforth [PB, 2011]) defines formal conditions for such transfer but falls short of providing an effective procedure for deciding whether transportability is feasible for a given set of assumptions about differences between the source and target domains. This paper provides such procedure. It establishes a necessary and sufficient condition for deciding when causal effects in the target domain are estimable from both the statistical information available and the causal information transferred from the experiments. The paper further provides a complete algorithm for computing the transport formula, that is, a way of fusing experimental and observational information to synthesize an estimate of the desired causal relation.
Bounds on Direct Effects in the Presence of Confounded Intermediate Variables
, 2007
"... Summary. This paper considers the problem of estimating the average controlled direct effect (ACDE) of a treatment on an outcome, in the presence of unmeasured confounders between an intermediate variable and the outcome. Such confounders render the direct effect unidentifiable even in cases where ..."
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Summary. This paper considers the problem of estimating the average controlled direct effect (ACDE) of a treatment on an outcome, in the presence of unmeasured confounders between an intermediate variable and the outcome. Such confounders render the direct effect unidentifiable even in cases where the total effect is unconfounded (hence identifiable). Kaufman et al. (2005) applied a linear programming software to find the minimum and maximum possible values of the ACDE for specific numerical data. In this paper, we apply the symbolic BalkePearl (1997) linear programming method to derive closedform formulas for the upper and lower bounds on the ACDE under various assumptions of monotonicity. These universal bounds enable clinical experimenters to assess the direct effect of treatment from observed data with minimum computational effort, and they further shed light on the sign of the direct effect and the accuracy of the assessments.