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Accounting for Model Uncertainty in Survival Analysis Improves Predictive Performance
 In Bayesian Statistics 5
, 1995
"... Survival analysis is concerned with finding models to predict the survival of patients or to assess the efficacy of a clinical treatment. A key part of the modelbuilding process is the selection of the predictor variables. It is standard to use a stepwise procedure guided by a series of significanc ..."
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Cited by 39 (12 self)
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Survival analysis is concerned with finding models to predict the survival of patients or to assess the efficacy of a clinical treatment. A key part of the modelbuilding process is the selection of the predictor variables. It is standard to use a stepwise procedure guided by a series of significance tests to select a single model, and then to make inference conditionally on the selected model. However, this ignores model uncertainty, which can be substantial. We review the standard Bayesian model averaging solution to this problem and extend it to survival analysis, introducing partial Bayes factors to do so for the Cox proportional hazards model. In two examples, taking account of model uncertainty enhances predictive performance, to an extent that could be clinically useful. 1 Introduction From 1974 to 1984 the Mayo Clinic conducted a doubleblinded randomized clinical trial involving 312 patients to compare the drug DPCA with a placebo in the treatment of primary biliary cirrhosis...
Bayesian Model Averaging in proportional hazard models: Assessing the risk of a stroke
 Applied Statistics
, 1997
"... Evaluating the risk of stroke is important in reducing the incidence of this devastating disease. Here, we apply Bayesian model averaging to variable selection in Cox proportional hazard models in the context of the Cardiovascular Health Study, a comprehensive investigation into the risk factors for ..."
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Cited by 28 (5 self)
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Evaluating the risk of stroke is important in reducing the incidence of this devastating disease. Here, we apply Bayesian model averaging to variable selection in Cox proportional hazard models in the context of the Cardiovascular Health Study, a comprehensive investigation into the risk factors for stroke. We introduce a technique based on the leaps and bounds algorithm which e ciently locates and ts the best models in the very large model space and thereby extends all subsets regression to Cox models. For each independent variable considered, the method provides the posterior probability that it belongs in the model. This is more directly interpretable than the corresponding Pvalues, and also more valid in that it takes account of model uncertainty. Pvalues from models preferred by stepwise methods tend to overstate the evidence for the predictive value of a variable. In our data Bayesian model averaging predictively outperforms standard model selection methods for assessing
A method for simultaneous variable selection and outlier identification in linear regression
 COMPUTATIONAL STATISTICS & DATA ANALYSIS
, 1996
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Change Point and Change Curve Modeling in Stochastic Processes and Spatial Statistics
 Journal of Applied Statistical Science
, 1993
"... In simple onedimensional stochastic processes it is feasible to model change points explicitly and to make inference about them. I have found that the Bayesian approach produces results more easily than nonBayesian approaches. It has the advantages of relative technical simplicity, theoretical opt ..."
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Cited by 9 (4 self)
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In simple onedimensional stochastic processes it is feasible to model change points explicitly and to make inference about them. I have found that the Bayesian approach produces results more easily than nonBayesian approaches. It has the advantages of relative technical simplicity, theoretical optimality, and of allowing a formal comparison between abrupt and gradual descriptions of change. When it can be assumed that there is at most one changepoint, this is especially simple. This is illustrated in the context of Poisson point processes. A simple approximation is introduced that is applicable to a wide range of problems in which the change point model can be written as a regression or generalized linear model. When the number of change points is unknown, the Bayesian approach proceeds most naturally by statespace modeling or "hidden Markov chains". The general ideas of this are briefly reviewed, particularly the multiprocess Kalman filter. I then describe the application of these...