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Dissociation between the effects of damage to perirhinal cortex and area TE
- Learning & Memory
, 1999
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Dissociation between striatal regions while learning to categorize via feedback and via observation
- Journal of Cognitive Neuroscience
, 2007
"... & Convergent evidence from functional imaging and from neuropsychological studies of basal ganglia disorders indicates that the striatum is involved in learning to categorize visual stimuli with feedback. However, it is unclear which cognitive process or processes involved in categorization is o ..."
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& Convergent evidence from functional imaging and from neuropsychological studies of basal ganglia disorders indicates that the striatum is involved in learning to categorize visual stimuli with feedback. However, it is unclear which cognitive process or processes involved in categorization is or are responsible for striatal recruitment; different regions of the striatum have been linked to feedback processing and to acquisition of stimulus– category associations. We examined the effect of the presence of feedback during learning on striatal recruitment by comparing feedback learning with observational learning of an information integration task. In the feedback task, participants were shown a stimulus, made a button press response, and then received feedback as to whether they had made the correct response. In the observational task, participants were given the category label before the stimulus appeared and then made a button press indicating the correct category membership. A region-of-interest analysis was used to examine activity in three regions of the striatum: the head of the caudate, body and tail of the caudate, and the putamen. Activity in the left head of the caudate was modulated by the presence of feedback: The magnitude of activation change was greater during feedback learning than during observational learning. In contrast, the bilateral body and tail of the caudate and the putamen were active to a similar degree in both feedback and observational learning. This pattern of results supports a functional dissociation between regions of the striatum, such that the head of the caudate is involved in feedback processing, whereas the body and tail of the caudate and the putamen are involved in learning stimulus– category associations. The hippocampus was active bilaterally during both feedback and observational learning, indicating potential parallel involvement with the striatum in information integration category learning. &
2000) Perception and recognition memory in monkeys following lesions of area TE and perirhinal cortex. Learn Mem 7:375–382
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An evaluation of the concurrent discrimination task as a measure of habit learning: Performance of amnesic subjects
- Neuropsychologia
, 1999
"... Habit learning has been defined as an association between a stimulus and a response that develops slowly and automatically through repeated reinforcement. Concurrent discrimination (CD) learning, in which subjects learn to choose the rewarded objects in a series of pairs, is believed to be an exampl ..."
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Habit learning has been defined as an association between a stimulus and a response that develops slowly and automatically through repeated reinforcement. Concurrent discrimination (CD) learning, in which subjects learn to choose the rewarded objects in a series of pairs, is believed to be an example of habit learning in monkeys. Studies of human amnesic subjects, however, have produced equivocal results, revealing impaired or absent learning on the same CD tasks that monkeys with medial temporal-lobe (MTL) lesions learn normally. One possible explanation for impaired performance in human amnesic subjects is that, unlike monkeys, human subjects use explicit memory to solve CD problems. To test this hypothesis, we administered a 10-object pair CD learning task to two amnesic subjects, HM and PN, and normal control subjects (NCS). Both amnesic subjects have severe anterograde amnesia with little ability to form explicit memories. On the CD task, they demonstrated little or no learning and acquired no explicit knowledge of the task procedures or reward contingencies. In contrast, NCS learned the task quickly and easily using explicit memory strategies. These results suggest that CD tasks cannot be learned by habit in human subjects, and emphasize the discrepancies between the human and monkey literature on habit
Learning to recognize visual objects with microstimulation in inferior temporal cortex
- J. Neurosci
, 2008
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You might find this additional info useful... This article cites 69 articles, 32 of which you can access for free at:
Differential Fos Expression Following Aspiration, Electrolytic, or Excitotoxic Lesions of the Perirhinal Cortex in Rats
"... The authors explored the possibility that there are different neural consequences, beyond the primary site of brain damage, following perirhinal cortex (PRh) lesions made in different ways. Fos expression was used as a marker for neuronal activation and compared across the forebrains of rats that un ..."
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The authors explored the possibility that there are different neural consequences, beyond the primary site of brain damage, following perirhinal cortex (PRh) lesions made in different ways. Fos expression was used as a marker for neuronal activation and compared across the forebrains of rats that underwent the different types of surgery. Electrolytic and excitotoxic PRh lesions produced dramatic increases in Fos expression in the cortex, and excitotoxic and aspiration PRh lesions increased Fos expression in the dentate gyrus. These data are consistent with the hypothesis that different lesion methods have separable effects on neural function in regions outside the lesion site that could account for inconsistencies in the literature regarding the behavioral effects of PRh lesions on tests of spatial memory.
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, 2007
"... Rats depend on habit memory for discrimination learning and retention ..."
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Rats depend on habit memory for discrimination learning and retention
Dissociation Between the Effects of Damage to Perirhinal Cortex and Area TE
"... Perirhinal cortex and area TE are immediately adjacent to each other in the temporal lobe and reciprocally interconnected. These areas are thought to lie at the interface between visual perception and visual memory, but it has been unclear what their separate contributions might be. In three experim ..."
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Perirhinal cortex and area TE are immediately adjacent to each other in the temporal lobe and reciprocally interconnected. These areas are thought to lie at the interface between visual perception and visual memory, but it has been unclear what their separate contributions might be. In three experiments, monkeys with bilateral lesions of the perirhinal cortex exhibited a different pattern of impairment than monkeys with bilateral lesions of area TE. In experiment 1, lesions of the perirhinal cortex produced a multimodal deficit in recognition memory (delayed nonmatching to sample), whereas lesions of area TE impaired performance only in the visual modality. In experiment 2, on a test of visual recognition memory (the visual paired comparison task) lesions of the perirhinal cortex impaired performance at long delays but spared performance at a very short delay. In contrast, lesions of area TE impaired performance even at the short delay. In experiment 3, lesions of the perirhinal cortex and lesions of area TE produced an opposite pattern of impairment on two visual discrimination tasks, simple object
Research Perception and Recognition Memory in Monkeys Following Lesions of Area TE and Perirhinal Cortex
"... Monkeys with lesions of perirhinal cortex (PR group) and monkeys with lesions of inferotemporal cortical area TE (TE group) were tested on a modified version of the delayed nonmatching to sample (DNMS) task that included very short delay intervals (0.5 sec) as well as longer delay intervals (1 min a ..."
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Monkeys with lesions of perirhinal cortex (PR group) and monkeys with lesions of inferotemporal cortical area TE (TE group) were tested on a modified version of the delayed nonmatching to sample (DNMS) task that included very short delay intervals (0.5 sec) as well as longer delay intervals (1 min and 10 min). Lesions of the perirhinal cortex and lesions of area TE produced different patterns of impairment. The PR group learned the DNMS task as quickly as normal monkeys (N) when the delay between sample and choice was very short (0.5 sec). However, performance of the PR group, unlike that of the N group, fell to chance levels when the delay between sample and choice was lengthened to 10 min. In contrast to the PR group, the TE group was markedly impaired on the DNMS task even at the 0.5-sec delay, and three of four monkeys with TE lesions failed to acquire the task. The results provide support for the idea that perirhinal cortex is important not for perceptual processing, but for the formation and maintenance of long-term memory. Area TE is important for the perceptual processing of visual stimuli. Recent findings demonstrated a double dissociation between the effects of two adjacent temporal lobe regions, the perirhinal cortex (PR) and inferotemporal cortical area TE (Buffalo et al. 1999). The pattern of findings suggested
Neuron Review: Point/Counterpoint Involvement of Medial Temporal Lobe Structures in Memory and Perception
"... Beginning approximately a decade and a half ago, it was suggested that some structures that are considered to be part of the ‘‘medial temporal lobe memory system’ ’ could play a role in perception as well. The implications of this view, interpreted broadly, are that medial temporal lobe structures m ..."
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Beginning approximately a decade and a half ago, it was suggested that some structures that are considered to be part of the ‘‘medial temporal lobe memory system’ ’ could play a role in perception as well. The implications of this view, interpreted broadly, are that medial temporal lobe structures may be understood as an extension of the ventral visual stream and that their functions cannot be described exclusively in terms of memory. Considerable evidence now supports the view that medial temporal lobe structures are involved in nonmnemonic aspects of cognition, such as perception. This discovery allows for a fuller understanding of the involvement of these structures in mental phenomena than does a purely mnemonic account of their function. See the related review by Suzuki, ‘‘Perception and the Medial Temporal Lobe: Evaluating the Current Evidence,’ ’ in this issue of Neuron. Structures in the medial temporal lobe (MTL), including the hippocampus and connected areas (entorhinal, perirhinal, parahippocampal cortex), have been proposed to constitute a ‘‘medial temporal lobe memory system’ ’ that is specialized for memory functions in the mammalian brain. Although it is acknowledged that these are not the only structures in the brain that are involved
