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N400-like Magnetoencephalography Responses Modulated by Semantic Context, Word Frequency, and Lexical Class in Sentences
, 2002
"... Words have been found to elicit a negative potential at the scalp peaking at �400 ms that is strongly modulated by semantic context. The current study used whole-head magnetoencephalography (MEG) as male subjects read sentences ending with semantically congruous or incongruous words. Compared with c ..."
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Words have been found to elicit a negative potential at the scalp peaking at �400 ms that is strongly modulated by semantic context. The current study used whole-head magnetoencephalography (MEG) as male subjects read sentences ending with semantically congruous or incongruous words. Compared with congruous words, sentence-terminal incongruous words consistently evoked a large magnetic field over the left hemisphere, peaking at �450 ms. Source modeling at this latency with conventional equivalent current dipoles (ECDs) placed the N400m generator in or near the left superior temporal sulcus. A distributed solution constrained to the cortical surface suggested a sequence of differential activation, beginning in Wernicke’s area at �250 ms, spreading to anterior temporal sites at �270 ms, to Broca’s area by
Cross-Cortical Consolidation as the Core Defect in Amnesia: Prospects for Hypothesis-Testing with Neuropsychology and Neuroimaging
"... iteria. Declarative Memory Observations of preserved and impaired memory in patients with amnesia indicate that the recall and recognition of facts and episodes, or declarative memory, is dependent on a particular subset of brain regions and can be disrupted selectively. How can we develop a bette ..."
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iteria. Declarative Memory Observations of preserved and impaired memory in patients with amnesia indicate that the recall and recognition of facts and episodes, or declarative memory, is dependent on a particular subset of brain regions and can be disrupted selectively. How can we develop a better understanding of this selectivity? Indeed, one might pose the question: Why is declarative memory different from all other forms of memory? Here are four answers to this question: 1. Because declarative memory has distinct behavioral characteristics. 2. Because declarative memory has distinct subjective characteristics. 3. Because declarative memory has a distinct cognitive structure. 4. Because declarative memory has distinct neural substrates. Memory theorists tend to give one or another of these answers greater emphasis, as discussed further below. In any event, determi

