### Biopharmaceutical

"... This issue of the Biopharmaceutical Report features a paper on the timely topic of data mining. We hope the paper will provoke further discussion among statisticians in the biopharmaceutical community, and lead to a better understanding of the issues raised by the authors. ..."

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This issue of the Biopharmaceutical Report features a paper on the timely topic of data mining. We hope the paper will provoke further discussion among statisticians in the biopharmaceutical community, and lead to a better understanding of the issues raised by the authors.

### Introduction to Statistical Practice

"... This is an informal course designed to: • review and interpret the principles underlying statistical practice, ..."

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This is an informal course designed to: • review and interpret the principles underlying statistical practice,

### Implementation of higher-order asymptotics to S-plus

, 2001

"... Higher-order asymptotics is an active area of development in theoretical statistics. However, most existing work in higher-order asymptotics is directed to the theoretical aspects. This paper attempts to incorporate higher-order inference procedures to S-plus, a widely used software in statistics. A ..."

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Higher-order asymptotics is an active area of development in theoretical statistics. However, most existing work in higher-order asymptotics is directed to the theoretical aspects. This paper attempts to incorporate higher-order inference procedures to S-plus, a widely used software in statistics. Algorithm is developed in the settings of generalized linear models and nonlinear regression models. The proposed algorithm generalizes the standard S-plus functions “glim” and “nls ” in the sense that both the rst-order and higher-order p-values are provided, and its

### Working Paper A11/01 Applications and Policy Statistics In Society: Three Case Studies In The UK

"... Public statistics are increasingly produced to facilitate public accountability and engagement at various levels of society i.e. to empower citizens. However, the impact of these statistics and their comprehension has not been systematically studied, indeed the arena in which statisticians work is g ..."

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Public statistics are increasingly produced to facilitate public accountability and engagement at various levels of society i.e. to empower citizens. However, the impact of these statistics and their comprehension has not been systematically studied, indeed the arena in which statisticians work is generally more technical and less oriented to public scrutiny. We explore the role of statistical literacy in citizenship and provide explanations as to how this is necessary to live up to normative ideals. Case studies show how statistics can create social reality, both in terms of categories and numerical summaries, although there may be more than one ‘data story ’ derived from the same information, as seen in the case of Mid Staffordshire Foundation Health Trust. Furthermore, public interpretations of these data stories need not be accurate and are rarely appropriate in their criticism of the objectivity represented by statistical analysis. Statistical description for a public audience requires much more than reporting figures relating to the phenomenon being described: such a presentation can be misleading or exclusive as well as restrict political discourse.

### binomial regression model with missing outcomes

, 2007

"... Likelihood estimation for a longitudinal negative ..."

### Accurate directional inference for vector parameters in linear exponential families

, 2013

"... We consider inference on a vector-valued parameter of interest in a linear exponential family, in the presence of a finite-dimensional nuisance parameter. Based on higher order asymptotic theory for likelihood, we propose a directional test whose p-value is computed using one-dimensional integration ..."

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We consider inference on a vector-valued parameter of interest in a linear exponential family, in the presence of a finite-dimensional nuisance parameter. Based on higher order asymptotic theory for likelihood, we propose a directional test whose p-value is computed using one-dimensional integration. For discrete responses this extends the development of Davison et al. (2006), and some of our examples concern testing in contingency tables. For continuous responses the work extends the directional test of Cheah et al. (1994). Examples and simulations illustrate the high accuracy of the method, which we compare with the usual likelihood ratio test and with an adjusted version due to Skovgaard (2001). In high-dimensional settings, such as covariance selection, the approach works essentially perfectly, whereas its competitors can fail catastrophically.

### Three case studies in the UK

"... Public statistics are increasingly produced to facilitate public accountability and engagement at various levels of society i.e. to empower citizens. However, the impact of these statistics and their comprehension has not been systematically studied, indeed the arena in which statisticians work is g ..."

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Public statistics are increasingly produced to facilitate public accountability and engagement at various levels of society i.e. to empower citizens. However, the impact of these statistics and their comprehension has not been systematically studied, indeed the arena in which statisticians work is generally more technical and less oriented to public scrutiny. We explore the role of statistical literacy in citizenship and provide explanations as to how this is necessary to live up to normative ideals. Case studies show how statistics can create social reality, both in terms of categories and numerical summaries, although there may be more than one ‘data story ’ derived from the same information, as seen in the case of Mid Staffordshire Foundation Health Trust. Furthermore, public interpretations of these data stories need not be accurate and are rarely appropriate in their criticism of the objectivity represented by statistical analysis. Statistical description for a public audience requires much more than reporting figures relating to the phenomenon being described: such a presentation can be misleading or exclusive as well as restrict political discourse.

### CERTAINTY AND UNCERTAINTY IN SCIENCE: THE SUBJECTIVISTIC CONCEPT OF PROBABILITY IN PHYSIOLOGY AND MEDICINE

, 2013

"... concept of probability in physiology and medicine. Certainty and uncertainty in science: the subjectivistic You might find this additional info useful... including high resolution figures, can be found at: Updated information and services ..."

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concept of probability in physiology and medicine. Certainty and uncertainty in science: the subjectivistic You might find this additional info useful... including high resolution figures, can be found at: Updated information and services

### unknown title

, 2009

"... mixed models for S language environments ASReml-R reference manual ASReml estimates variance components under a general linear mixed model by residual maximum likelihood (REML) D.G. Butler ..."

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mixed models for S language environments ASReml-R reference manual ASReml estimates variance components under a general linear mixed model by residual maximum likelihood (REML) D.G. Butler