Routing with time windows (VRPTW) has been an area of research that have attracted many researchers within the last 10 { 15 years. In this period a number of papers and technical reports have been published on the exact solution of the VRPTW. The VRPTW is a generalization of the well-known capacitated routing problem (VRP or CVRP). In the VRP a eet of vehicles must visit (service) a number of customers. All vehicles start and end at the depot. For each pair of customers or customer and depot there is a cost. The cost denotes how much is costs a vehicle to drive from one customer to another. Every customer must be visited exactly ones. Additionally each customer demands a certain quantity of goods delivered (know as the customer demand). For the vehicles we have an upper limit on the amount of goods that can be carried (known as the capacity). In the most basic case all vehicles are of the same type and hence have the same capacity. The problem is now for a given scenario to plan routes for the vehicles in accordance with the mentioned constraints such that the cost accumulated on the routes, the xed costs (how much does it cost to maintain a vehicle) or a combination hereof is minimized. In the more general VRPTW each customer has a time window, and between all pairs of customers or a customer and the depot we have a travel time. The vehicles now have to comply with the additional constraint that servicing of the customers can only be started within the time windows of the customers. It is legal to arrive before a time window \opens" but the vehicle must wait and service will not start until the time window of the customer actually opens. For solving the problem exactly 4 general types of solution methods have evolved in the literature: dynamic programming, Dantzig-Wolfe (column generation), Lagrange decomposition and solving the classical model formulation directly. Presently the algorithms that uses Dantzig-Wolfe given the best results (Desrochers, Desrosiers and Solomon, and Kohl), but the Ph.D. thesis of Kontoravdis shows promising results for using the classical model formulation directly. In this Ph.D. project we have used the Dantzig-Wolfe method. In the Dantzig-Wolfe method the problem is split into two problems: a \master problem" and a \subproblem". The master problem is a relaxed set partitioning v vi problem that guarantees that each customer is visited exactly ones, while the subproblem is a shortest path problem with additional constraints (capacity and time window). Using the master problem the reduced costs are computed for each arc, and these costs are then used in the subproblem in order to generate routes from the depot and back to the depot again. The best (improving) routes are then returned to the master problem and entered into the relaxed set partitioning problem. As the set partitioning problem is relaxed by removing the integer constraints the solution is seldomly integral therefore the Dantzig-Wolfe method is embedded in a separation-based solution-technique. In this Ph.D. project we have been trying to exploit structural properties in order to speed up execution times, and we have been using parallel computers to be able to solve problems faster or solve larger problems. The thesis starts with a review of previous work within the eld of VRPTW both with respect to heuristic solution methods and exact (optimal) methods. Through a series of experimental tests we seek to dene and examine a number of structural characteristics. The rst series of tests examine the use of dividing time windows as the branching principle in the separation-based solution-technique. Instead of using the methods previously described in the literature for dividing a problem into smaller problems we use a methods developed for a variant of the VRPTW. The results are unfortunately not positive. Instead of dividing a problem into two smaller problems and try to solve these we can try to get an integer solution without having to branch. A cut is an inequality that separates the (non-integral) optimal solution from all the integer solutions. By nding and inserting cuts we can try to avoid branching. For the VRPTW Kohl has developed the 2-path cuts. In the separationalgorithm for detecting 2-path cuts a number of test are made. By structuring the order in which we try to generate cuts we achieved very positive results. In the Dantzig-Wolfe process a large number of columns may be generated, but a signicant fraction of the columns introduced will not be interesting with respect to the master problem. It is a priori not possible to determine which columns are attractive and which are not, but if a column does not become part of the basis of the relaxed set partitioning problem we consider it to be of no benet for the solution process. These columns are subsequently removed from the master problem. Experiments demonstrate a signicant cut of the running time. Positive results were also achieved by stopping the route-generation process prematurely in the case of time-consuming shortest path computations. Often this leads to stopping the shortest path subroutine in cases where the information (from the dual variables) leads to \bad" routes. The premature exit from the shortest path subroutine restricts the generation of \bad" routes signi cantly. This produces very good results and has made it possible to solve problem instances not solved to optimality before. The parallel algorithm is based upon the sequential Dantzig-Wolfe based algorithm developed earlier in the project. In an initial (sequential) phase unsolved problems are generated and when there are unsolved problems enough vii to start work on every processor the parallel solution phase is initiated. In the parallel phase each processor runs the sequential algorithm. To get a good workload a strategy based on balancing the load between neighbouring processors is implemented. The resulting algorithm is eÆcient and capable of attaining good speedup values. The loadbalancing strategy shows an even distribution of work among the processors. Due to the large demand for using the IBM SP2 parallel computer at UNIC it has unfortunately not be possible to run as many tests as we would have liked. We have although managed to solve one problem not solved before using our parallel algorithm.

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Designing pickup protocols for materials returning on a delivery route is the focus of this paper. Pickup strategies on a fixed route are influenced by variables such as the number of stops on the route, the variability of stop demand, delivery vehicle capacity, the use of outside carriers to supplement delivery vehicle capacity, the number of periods for planning, the penalty cost for not picking up returning materials promptly. Three special cases are identified where the problem is analytically tractable. For the general problem where customers have different penalty costs for materials not returned promptly, an efficient heuristic procedure is proposed. Several insightful rules for route management resulting from this analysis are offered. i 1

Abstract—Medical services are usually provided in hospitals; however, in developing country, some rural residences have fewer opportunities to access in healthcare services due to the limitation of transportation communication. Therefore, in Thailand, there are charitable organizations operating to provide medical treatments to these people by shifting the medical services to operation sites; this is commonly known as mobile medical service. Operation routing is important for the organization to reduce its transportation cost in order to focus more on other important activities; for instance, the development of medical apparatus. VRP is applied to solve the problem of high transportation cost of the studied organization with the searching techniques of saving algorithm to find the minimum total distance of operation route and satisfy available time constraints of voluntary medical staffs.

The Vehicle Routing Problem is one of the most studied areas in literature, mainly because of the real world logistics and transportation problems related to it. In the present paper, a new two-stage approach for solving a speci c real problem is shown, along with a decision making software. In the rst stage all the feasible routes are generated by means of an implicit enumeration algorithm, afterwards, all the information gathered is used by an integer programming model that determines the optimum set of routes for the given demand. The integer model uses a number of 0-1 variables ranging from 2,000 to 15,000 and gives optimum solutions in an average of 60 seconds. An interactive Decision Support System was also developed to help the user in the dierent aspects of the route scheduling process. In a worst-case scenario, the schedules obtained range from a 7% to 12% reduction in the distance travelled and from a 9% to 11% reduction in operational costs.