Characterizing the performance of image segmentation approaches has been a persistent challenge. Performance analysis is important since segmentation algorithms often have limited accuracy and precision. Interactive drawing of the desired segmentation by human raters has often been the only acceptable approach, and yet suffers from intrarater and inter-rater variability. Automated algorithms have been sought in order to remove the variability introduced by raters, but such algorithms must be assessed to ensure they are suitable for the task. The performance of raters...

While level sets have demonstrated a great potential for 3D medical image segmentation, their usefulness has been limited by two problems. First, 3D level sets are relatively slow to compute. Second, their formulation usually entails several free parameters which can be very di#cult to correctly tune for specific applications. The second problem is compounded by the first. This paper presents a tool for 3D segmentation that relies on level-set surface models computed at interactive rates on commodity graphics cards (GPUs). The mapping of a level-set solver to a GPU relies on a novel mechanism for GPU memory management. The interactive rates for solving the levelset PDE give the user immediate feedback on the parameter settings, and thus users can tune three separate parameters and control the shape of the model in real time. We have found that this interactivity...

While level sets have demonstrated a great potential for 3D medical image segmentation, their usefulness has been limited by two problems. First, 3D level sets are relatively slow to compute. Second, their formulation usually entails several free parameters which can be very difficult to correctly tune for specific applications. The second problem is compounded by the first. This paper describes a new tool for 3D segmentation that addresses these problems by computing level-set surface models at interactive rates. This tool employs two important, novel technologies. First is the mapping of a 3D level-set solver onto a commodity graphics card (GPU). This mapping relies on a novel mechanism for GPU memory management. The interactive rates level-set PDE solver give the user immediate feedback on the parameter settings, and thus users can tune free parameters and control the shape of the model in real time. The second technology is the use of region-based speed functions, which allow a user to quickly and intuitively specify the behavior of the deformable model. We have found that the combination of these interactive tools enables users to produce good, reliable segmentations. To support this observation, this paper presents qualitative results from several different datasets as well as a quantitative evaluation from a study of brain tumor segmentations.

In this paper we present a new algorithm for 3D medical image segmentation. The algorithm is versatile, fast, relatively simple to implement, and semi-automatic. It is based on minimizing a global energy defined from a learned non-parametric estimation of the statistics of the region to be segmented. Implementation details are discussed and source code is freely available as part of the 3D Slicer project. In addition, a new unified set of validation metrics is proposed. Results on artificial and real MRI images show that the algorithm performs well on large brain structures both in terms of accuracy and robustness to noise.

An extension of the gradient vector flow snake (GVF snake) is presented. The method is based on combining two other external forces. First, the adaptive balloon force has been developed to increase the GVF snake's capture range and convergence speed. Then, a dynamic GVF force is introduced to provide an efficient evolution-stop mechanism. In this way, we prevent the snake from breaking through the correct surface and locking to other salient feature points. Preliminary segmentation results demonstrate the potential of our approach in comparison with the original GVF snake method.