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...T Journals on M arch 4, 2016 jpet.aspetjournals.org D ow nloaded from fects and central antihyperalgesic effects to carrageenan through the activation of peroxisome proliferator-activated receptor (=-=LoVerme et al., 2006-=-; D’Agostino et al., 2009), raising the possibility that other substrates of FAAH could reduce the hyperalgesic and inflammatory actions of intraplantar LPS. The critical involvement of CB1 and CB2 in...

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...(Howlett et al., 2004). Recently, additional cellular targets of endocannabinoid lipids have been discovered, including ion channels (Movahed et al., 2005; Oz et al., 2005) and transcription factors (=-=LoVerme et al., 2006-=-). The steady state levels of NAEs are likely important to their signaling function and are determined by the tight control of their formation and degradation. Recent advances in our understanding of ...

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...6 is not a CB1 receptor agonist. Previous reports indicate that a-truxillic acid derivatives activate peroxisome proliferator-activated receptor c (PPARc), which alongside PPARa, modulate nociception =-=[17,18,19]-=-. In our hands, SB-FI-26 served as a weak agonist at both receptors, displaying ,2-fold activation of PPARa and ,3-fold activation of PPARc (Figure 11C, 11D). Figure 5. Four compounds from the FABP7 c...

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...d ethanolamides along with OEA. At present, the functional roles played by each member of this family of compounds, if any, remain unclear. Because both OEA and PEA activate PPAR- and reduce feeding =-=(11, 18)-=-, the possibility that PEA contributes to the hypophagic effect of NAPE-PLD overexpression should be taken into consideration. The second question relates to the cell types in the small intestine (5) ...

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...sted that it activates the peroxisomesproliferator-activated receptor α pathway. These mechanisms have been proposed to cause itssanti-nociceptive and anti-inflammatory effects (Lambert et al., 2002; =-=LoVerme et al., 2006-=-).sResearch involving the development of a novel analogue of palmitoylethonolamide has shownssuccessful antinocieption properties with no side effects when administrated locally (RoaCoria et al., 2012...

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... DEX (2 mg/kg i.p.), or vehicle (VEH) was administered 1 h before and 6 and 23 h after LPS. The mice were humanely euthanized at 24 h, and paws were harvested. Pretreatment with URB or DEX significantly attenuated LPS-induced IL-1 expression (A) and TNF- (B). , p 0.0001 compared with the vehicle plus saline (VEHSAL) group. †, p 0.05; ††, p 0.01; †††, p 0.001 compared with VEHLPS group. n 12 mice per group. Data are depicted as means S.E.M. 188 Naidu et al. fects and central antihyperalgesic effects to carrageenan through the activation of peroxisome proliferator-activated receptor (LoVerme et al., 2006; D’Agostino et al., 2009), raising the possibility that other substrates of FAAH could reduce the hyperalgesic and inflammatory actions of intraplantar LPS. The critical involvement of CB1 and CB2 in the respective antihyperalgesic and antiedematous phenotypes of FAAH-disrupted mice implicates anandamide as an important mediator of these effects, especially given that neither PEA nor OEA binds to cannabinoid receptors, although the possibility that other substrates of FAAH contribute to these actions cannot be ruled out. The observation that FAAH can hydrolyze both anandamide and 2-AG at simi...