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This thesis investigates feedforward neural networks in the context of classification tasks with respect to the detection of patterns that do not belong to the same categories of patterns used to train the network. This refers to the problem of the detection and/or rejection of spurious or novel patterns. In particular, the multilayer perceptron network (MLP) trained with the backpropagation algorithm is examined in this respect and different strategies for improving its performance in the detection of spurious patterns are considered. The problem is investigated from different points of view that vary from the modification of the multilayer perceptron network with different configurations that make it more intrinsically able to detect spurious information, to the introduction of novel auxiliary mechanisms which, when integrated with the MLP network, can provide an overall enhancement in the system's rejection capabilities. These different network configurations are examined with respe...