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Mapping motor inhibition: Conjunctive brain activations across different versions of go/no-go and stop tasks. NeuroImage 13: 250–261
, 2001
"... Conjunction analysis methods were used in functional magnetic resonance imaging to investigate brain regions commonly activated in subjects performing different versions of go/no-go and stop tasks, differing in probability of inhibitory signals and/or contrast conditions. Generic brain activation ma ..."
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Cited by 120 (0 self)
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Conjunction analysis methods were used in functional magnetic resonance imaging to investigate brain regions commonly activated in subjects performing different versions of go/no-go and stop tasks, differing in probability of inhibitory signals and/or contrast conditions. Generic brain activation maps highlighted brain regions commonly activated in (a) two different go/no-go task versions, (b) three different stop task versions, and (c) all 5 inhibition task versions. Comparison between the generic activation maps of stop and go/no-go task versions revealed inhibitory mechanisms specific to go/no-go or stop task performance in 15 healthy, right-handed, male adults. In the go/no-go task a motor response had to be selectively executed or inhibited in either 50 % or 30 % of
Where and when to pay attention: The neural systems for directing attention to spatial locations and to time intervals as revealed by both PET and fMRI
, 1998
"... Although attention is distributed across time as well as space, the temporal allocation of attention has been less well re-searched than its spatial counterpart. A temporal analog of the covert spatial orientation task [Posner MI, Snyder CRR, David-son BJ (1980) Attention and the detection of signal ..."
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Cited by 106 (6 self)
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Although attention is distributed across time as well as space, the temporal allocation of attention has been less well re-searched than its spatial counterpart. A temporal analog of the covert spatial orientation task [Posner MI, Snyder CRR, David-son BJ (1980) Attention and the detection of signals. J Exp Psychol Gen 109:160–174] was developed to compare the neural systems involved in directing attention to spatial loca-tions versus time intervals. We asked whether there exists a general system for allocating attentional resources, indepen-dent of stimulus dimension, or whether functionally specialized brain regions are recruited for directing attention toward spatial versus temporal aspects of the environment. We measured brain activity in seven healthy volunteers by using positron emission tomography (PET) and in eight healthy volunteers by using functional magnetic resonance imaging (fMRI). The task
Maturation of widely distributed brain function subserves cognitive development
- NeuroImage
, 2001
"... Cognitive and brain maturational changes continue throughout late childhood and adolescence. During this time, increasing cognitive control over behavior enhances the voluntary suppression of reflexive/impulsive response tendencies. Recently, with the advent of functional MRI, it has become possible ..."
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Cited by 87 (5 self)
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Cognitive and brain maturational changes continue throughout late childhood and adolescence. During this time, increasing cognitive control over behavior enhances the voluntary suppression of reflexive/impulsive response tendencies. Recently, with the advent of functional MRI, it has become possible to characterize changes in brain activity during cognitive development. In order to investigate the cognitive and brain maturation subserving the ability to voluntarily suppress context-inappropriate behavior, we tested 8–30 year olds in an oculomotor response–suppression task. Behavioral results indicated that adult-like ability to inhibit prepotent responses matured gradually through childhood and adolescence. Functional MRI results indicated that brain activation in frontal, parietal, striatal, and thalamic regions increased progressively from childhood to adulthood. Prefrontal cortex was more active in adolescents than in children or adults; adults demonstrated greater activation in the lateral cerebellum than younger subjects. These results suggest that efficient top-down modulation of reflexive acts may not be fully developed until adulthood and provide evidence that maturation of function across widely distributed brain regions lays the groundwork for enhanced voluntary control of behavior during cognitive development. © 2001 Academic Press Key Words: inhibition; eye movements; cerebellum; neuroimaging.
Role of the human medial frontal cortex in task switching: A combined fMRI and TMS study
- Journal of Neurophysiology
, 2002
"... of the human medial frontal cortex in task switching: a combined ..."
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Cited by 66 (1 self)
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of the human medial frontal cortex in task switching: a combined
Transition of brain activation from frontal to parietal areas in visuomotor sequence learning
- Journal of Neuroscience
, 1998
"... We studied the neural correlates of visuomotor sequence learning using functional magnetic resonance imaging (fMRI). In the test condition, subjects learned, by trial and error, the correct order of pressing two buttons consecutively for 10 pairs of buttons (2 � 10 task); in the control condition, t ..."
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Cited by 64 (3 self)
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We studied the neural correlates of visuomotor sequence learning using functional magnetic resonance imaging (fMRI). In the test condition, subjects learned, by trial and error, the correct order of pressing two buttons consecutively for 10 pairs of buttons (2 � 10 task); in the control condition, they pressed buttons in any order. Comparison between the test condition and the control condition revealed four brain areas specifically related to learning: the dorsolateral prefrontal cortex (DLPFC), the presupplementary motor area (pre-SMA), the precuneus, and the intraparietal sulcus (IPS). We found that the time course of activation during learning was different between these areas. To normalize the individual differences in the speed of learning, we classified the performance of each subject into three learning stages: early, intermediate, and advanced stages. Both the relative increase of signal intensity and the number of activated
The mental number line and the human angular gyrus
- Neuroimage
, 2001
"... To investigate the hemispheric organization of a language-independent spatial representation of number magnitude in the human brain we applied focal repetitive transcranial magnetic stimulation (rTMS) to the right or left angular gyrus while subjects performed a number comparison task with numbers b ..."
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Cited by 51 (0 self)
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To investigate the hemispheric organization of a language-independent spatial representation of number magnitude in the human brain we applied focal repetitive transcranial magnetic stimulation (rTMS) to the right or left angular gyrus while subjects performed a number comparison task with numbers between 31 and 99. Repetitive TMS over the angular gyrus disrupted performance of a visuospatial search task, and rTMS at the same site disrupted organization of the putative “number line. ” In some cases the pattern of disruption caused by angular gyrus rTMS suggested that this area normally mediates a spatial representation of number. The effect of angular gyrus rTMS on the number line task was specific. rTMS had no disruptive effect when delivered over another parietal region, the supramarginal gyrus, in either the left or the right hemisphere. © 2001 Academic Press
Brain areas specific for attentional load in a motion-tracking task
- Journal of Cognitive Neuroscience
, 2001
"... INTRODUCTION: The aim of this study was to investigate the neural basis for attentional load effects in humans. Although recent neuroimaging studies (1,2,3) suggest the involvement of parietal cortex, MT/V5 complex and prefrontal cortex in the regulation of visual attention of ..."
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Cited by 45 (4 self)
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INTRODUCTION: The aim of this study was to investigate the neural basis for attentional load effects in humans. Although recent neuroimaging studies (1,2,3) suggest the involvement of parietal cortex, MT/V5 complex and prefrontal cortex in the regulation of visual attention of
Abstract and effector-specific representations of motor sequences identified with PET
- Journal of Neuroscience
, 1998
"... Positron emission tomography was used to identify neural sys-tems involved in the acquisition and expression of sequential movements produced by different effectors. Subjects were tested on the serial reaction time task under implicit learning conditions. In the initial acquisition phase, subjects r ..."
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Cited by 43 (8 self)
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Positron emission tomography was used to identify neural sys-tems involved in the acquisition and expression of sequential movements produced by different effectors. Subjects were tested on the serial reaction time task under implicit learning conditions. In the initial acquisition phase, subjects responded to the stimuli with keypresses using the four fingers of the right hand. During this phase, the stimuli followed a fixed sequence for one group of subjects (group A) and were randomly selected for another group (group B). In the transfer phase, arm move-ments were used to press keys on a substantially larger key-board, and for both groups, the stimuli followed the sequence. Behavioral indices provided clear evidence of learning during the acquisition phase for group A and transfer when switched to the large keyboard. Sequence acquisition was associated with learning-related increases in regional cerebral blood flow
Attention systems and the organization of human parietal cortex
- J. Neurosci
, 2001
"... Event-related functional magnetic resonance imaging was used to compare activity in the human parietal cortex in two attention-switching paradigms. On each trial of the visual switching (VS) paradigm, subjects attended to one of two visual stimuli on the basis of either their color or shape. Trials ..."
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Cited by 41 (1 self)
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Event-related functional magnetic resonance imaging was used to compare activity in the human parietal cortex in two attention-switching paradigms. On each trial of the visual switching (VS) paradigm, subjects attended to one of two visual stimuli on the basis of either their color or shape. Trials were presented in blocks interleaved with cues instructing subjects to either continue attending to the currently relevant dimension or to switch to the other stimulus dimension. In the response switching (RS) paradigm, subjects made one of two manual responses to the single stimulus presented on each trial. The rules for stimulus–response mapping were reversed on different trials. Trials were presented in blocks interleaved with cues that instructed subjects to either switch stimulus–response mapping rules or to continue with the current rule. Brain activity at “switch ” and “stay ” events was compared. The results revealed
Neural topography and content of movement representations
- Journal of Cognitive Neuroscience
, 2005
"... Abstract & We have used implicit motor imagery to investigate the neural correlates of motor planning independently from actual movements. Subjects were presented with drawings of left or right hands and asked to judge the hand laterality, regardless of the stimulus rotation from its upright or ..."
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Cited by 32 (7 self)
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Abstract & We have used implicit motor imagery to investigate the neural correlates of motor planning independently from actual movements. Subjects were presented with drawings of left or right hands and asked to judge the hand laterality, regardless of the stimulus rotation from its upright orientation. We paired this task with a visual imagery control task, in which subjects were presented with typographical characters and asked to report whether they saw a canonical letter or its mirror image, regardless of its rotation. We measured neurovascular activity with fast event-related fMRI, distinguishing responses parametrically related to motor imagery from responses evoked by visual imagery and other task-related phenomena. By quantifying behavioral and neurovascular correlates of imagery on a trial-by-trial basis, we could discriminate between stimulusrelated, mental rotation-related, and response-related neural activity. We found that specific portions of the posterior parietal and precentral cortex increased their activity as a function of mental rotation only during the motor imagery task. Within these regions, the parietal cortex was visually responsive, whereas the dorsal precentral cortex was not. Response-but not rotation-related activity was found around the left central sulcus (putative primary motor cortex) during both imagery tasks. Our study provides novel evidence on the topography and content of movement representations in the human brain. During intended action, the posterior parietal cortex combines somatosensory and visuomotor information, whereas the dorsal premotor cortex generates the actual motor plan, and the primary motor cortex deals with movement execution. We discuss the relevance of these results in the context of current models of action planning. &