Ways of obtaining approximate Bayes factors for generalized linear models are described, based on the Laplace method for integrals. I propose a new approximation which uses only the output of standard computer programs such as GUM; this appears to be quite accurate. A reference set of proper priors is suggested, both to represent the situation where there is not much prior information, and to assess the sensitivity of the results to the prior distribution. The methods can be used when the dispersion parameter is unknown, when there is overdispersion, to compare link functions, and to compare error distributions and variance functions. The methods can be used to implement the Bayesian approach to accounting for model uncertainty. I describe an application to inference about relative risks in the presence of control factors where model uncertainty is large and important. Software to implement the

Maximum a posterJori optimization of parameters and the Laplace approximation for the marginal likelihood are both basis-dependent methods. This note compares two choices of basis for models parameterized by probabilities, showing that it is possible to improve on the traditional choice, the probability simplex, by transforming to the softmax' basis.

Laplace's method, a family of asymptotic methods used to approximate integrals, is presented as a potential candidate for the tool box of techniques used for knowledge acquisition and probabilistic inference in belief networks with continuous variables. This technique approximates posterior moments and marginal posterior distributions with reasonable accuracy [errors are O(n,2) for posterior means] in many interesting cases. The method also seems promising for computing approximations for Bayes factors for use in the context of model selection, model uncertainty and mixtures of pdfs. The limitations, regularity conditions and computational di culties for the implementation of Laplace's method are comparable to those associated with the methods of maximum likelihood and posterior mode analysis. 1